Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity Journal Article

   

Authors:	Wibmer, A. G.; Becher, T.; Eljalby, M.; Crane, A.; Causa Andrieu, P.; Jiang, C. S.; Vaughan, R.; Schöder, H.; Cohen, P.
Article Title:	Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity
Abstract:	The association of brown adipose tissue (BAT) and body fat distribution and their combined effects on metabolic health in humans remains unknown. Here, we retrospectively identify individuals with and without BAT on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and assemble a propensity score-matched study cohort to compare body fat distribution and determine its role in mediating the benefits of brown fat. We find that BAT is associated with lower amounts of visceral adipose tissue and higher amounts of subcutaneous adipose tissue, resulting in less central obesity. In addition, BAT is independently associated with lower blood glucose and white blood cell count, improved lipids, lower prevalence of type 2 diabetes mellitus, and decreased liver fat accumulation. These observations are most prominent in individuals with central obesity. Our results support a role of BAT in protection from visceral adiposity and improved metabolic health. © 2021 The Author(s)
Keywords:	brown fat; lipid metabolism; glucose metabolism; brown adipose tissue; subcutaneous fat; visceral fat; visceral obesity; hepatic steatosis; type 2 diabetes mellitus; metabolic health
Journal Title:	Cell Reports Medicine
Volume:	2
Issue:	7
ISSN:	2666-3791
Publisher:	Cell Press
Date Published:	2021-07-20
Start Page:	100332
Language:	English
DOI:	10.1016/j.xcrm.2021.100332
PROVIDER:	scopus
PMCID:	PMC8324464
PUBMED:	34337558
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110573284&doi=10.1016%2fj.xcrm.2021.100332&partnerID=40&md5=4384586c960211c3879faaeff356dad8
Notes:	Article -- Export Date: 2 August 2021 -- Source: Scopus

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