New insights into promoter-enhancer communication mechanisms revealed by dynamic single-molecule imaging Review
| Authors: | Li, J.; Pertsinidis, A. |
| Review Title: | New insights into promoter-enhancer communication mechanisms revealed by dynamic single-molecule imaging |
| Abstract: | Establishing cell-type-specific gene expression programs relies on the action of distal enhancers, cis-regulatory elements that can activate target genes over large genomic distances - up to Mega-bases away. How distal enhancers physically relay regulatory information to target promoters has remained a mystery. Here, we review the latest developments and insights into promoter-enhancer communication mechanisms revealed by live-cell, real-time single-molecule imaging approaches. © 2021 The Author(s). |
| Keywords: | promoter region; review; enhancer region; single molecule imaging |
| Journal Title: | Biochemical Society Transactions |
| Volume: | 49 |
| Issue: | 3 |
| ISSN: | 0300-5127 |
| Publisher: | Portland Press Ltd |
| Date Published: | 2021-06-01 |
| Start Page: | 1299 |
| End Page: | 1309 |
| Language: | English |
| DOI: | 10.1042/bst20200963 |
| PUBMED: | 34060610 |
| PROVIDER: | scopus |
| PMCID: | PMC8325597 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2021 -- Source: Scopus |
