Bacterial DNA repair by non-homologous end joining Journal Article
| Authors: | Shuman, S.; Glickman, M. S. |
| Article Title: | Bacterial DNA repair by non-homologous end joining |
| Abstract: | The capacity to rectify DNA double-strand breaks (DSBs) is crucial for the survival of all species. DSBs can be repaired either by homologous recombination (HR) or non-homologous end joining (NHEJ). The long-standing notion that bacteria rely solely on HR for DSB repair has been overturned by evidence that mycobacteria and other genera have an NHEJ system that depends on a dedicated DNA ligase, LigD, and the DNA-end-binding protein Ku. Recent studies have illuminated the role of NHEJ in protecting the bacterial chromosome against DSBs and other clastogenic stresses. There is also emerging evidence of functional crosstalk between bacterial NHEJ proteins and components of other DNA-repair pathways. Although still a young field, bacterial NHEJ promises to teach us a great deal about the nexus of DNA repair and bacterial pathogenesis. |
| Keywords: | unclassified drug; review; nonhuman; dna polymerase; protein domain; dna recombination; homologous recombination; dna repair; phosphatase; enzyme activity; bacteria (microorganisms); dna strand breakage; double stranded dna; recombination, genetic; dna breaks, double-stranded; base pairing; ku antigen; gene insertion; polydeoxyribonucleotide synthase; enzyme structure; bacterial dna; mycobacterium; corynebacterineae; dna, bacterial; virus cell interaction; bacterial physiology; polydeoxyribonucleotide synthase d |
| Journal Title: | Nature Reviews Microbiology |
| Volume: | 5 |
| Issue: | 11 |
| ISSN: | 1740-1526 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-11-01 |
| Start Page: | 852 |
| End Page: | 861 |
| Language: | English |
| DOI: | 10.1038/nrmicro1768 |
| PUBMED: | 17938628 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 17 November 2011" - "CODEN: NRMAC" - "Source: Scopus" |
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