Immunotherapeutic strategies for high-risk bladder cancer Journal Article
| Authors: | Sharma, P.; Old, L. J.; Allison, J. P. |
| Article Title: | Immunotherapeutic strategies for high-risk bladder cancer |
| Abstract: | Transitional cell carcinoma (TCC), which is the pathological diagnosis for the majority of bladder cancers, is a solid tumor entity that is responsive to immunotherapy as evidenced by a substantial cure rate documented with the use of intravesical bacillus Calmette-Guérin (BCG) therapy in selected patients with high-grade superficial disease. The nonspecific immune modulation that occurs as a result of BCG therapy is not well understood; however, the success of BCG therapy provides a basis for the exploration of mechanisms related to immune responses and the development of novel immunotherapeutic agents for the treatment of high-risk disease. In this review, we discuss the complexity of the immune system and therapies that are considered capable of manipulating it to potentially benefit patients with bladder cancer. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | treatment response; cancer risk; solid tumor; t lymphocyte; tumor associated leukocyte; bcg vaccine; cancer immunotherapy; gene expression; granulocyte macrophage colony stimulating factor; bladder cancer; urinary bladder neoplasms; high risk patient; lymphocyte activation; immune response; immunotherapy; cytokine production; innate immunity; immunomodulation; adaptive immunity; cytotoxic t lymphocyte antigen 4; carcinoma, transitional cell; transitional cell carcinoma; serology; antigen antibody complex; major histocompatibility antigen |
| Journal Title: | Seminars in Oncology |
| Volume: | 34 |
| Issue: | 2 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-04-01 |
| Start Page: | 165 |
| End Page: | 172 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2006.12.004 |
| PUBMED: | 17382800 |
| PROVIDER: | scopus |
| PMCID: | PMC6009830 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: SOLGA" - "Source: Scopus" |
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