(225)actinium-labeled prostate-specific membrane antigen targeting peptide induces complete response in a metastatic prostate cancer patient Journal Article
| Authors: | Aras, O.; Harmsen, S.; Ting, R.; Sayman, H. B. |
| Article Title: | (225)actinium-labeled prostate-specific membrane antigen targeting peptide induces complete response in a metastatic prostate cancer patient |
| Abstract: | Targeted radionuclide therapy has emerged as a promising and potentially curative strategy for high-grade prostate cancer. However, limited data are available on efficacy, quality of life, and pretherapeutic biomarkers. Here, we highlight the case of a patient with prostate-specific membrane antigen (PSMA)-positive metastatic castrate-resistant prostate cancer who displayed complete response to Ac-225-PSMA-617 after having been resistant to standard-of-care therapy, then initially partially responsive but later resistant to subsequent immunotherapy, and resistant to successive Lu-177-PSMA-617. In addition, the patient's baseline germline mutation likely predisposed him to more aggressive disease. |
| Keywords: | ipilimumab; radiation; genetic; alterations; metastatic prostate cancer; mcrpc; radioligand therapy; ac-225-psma |
| Journal Title: | Acta Radiologica Open |
| Volume: | 10 |
| Issue: | 5 |
| ISSN: | 2058-4601 |
| Publisher: | Sage Publications |
| Date Published: | 2021-05-01 |
| Language: | English |
| ACCESSION: | WOS:000656515800001 |
| DOI: | 10.1177/20584601211022509 |
| PROVIDER: | wos |
| PMCID: | PMC8172952 |
| PUBMED: | 34104479 |
| Notes: | Article -- Source: Wos |
