Ribozymes, riboswitches and beyond: Regulation of gene expression without proteins Journal Article
| Authors: | Serganov, A.; Patel, D. J. |
| Article Title: | Ribozymes, riboswitches and beyond: Regulation of gene expression without proteins |
| Abstract: | Although various functions of RNA are carried out in conjunction with proteins, some catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little or no assistance from proteins. Furthermore, the discovery of metabolite-sensing riboswitches and other types of RNA sensors has revealed RNA-based mechanisms that cells use to regulate gene expression in response to internal and external changes. Structural studies have shown how these RNAs can carry out a range of functions. In addition, the contribution of ribozymes and riboswitches to gene expression is being revealed as far more widespread than was previously appreciated. These findings have implications for understanding how cellular functions might have evolved from RNA-based origins. © 2007 Nature Publishing Group. |
| Keywords: | review; nonhuman; binding affinity; animals; cell function; gene expression; gene function; evolution; structure activity relation; structure-activity relationship; evolution, molecular; rna; gene expression regulation; gene control; models, molecular; thermodynamics; binding sites; catalysis; nucleic acid conformation; protein folding; structure analysis; temperature measurement; catalytic domain; bacterium; rna splicing; regulatory sequences, ribonucleic acid; riboswitch; sensor; ribozyme; rna, catalytic |
| Journal Title: | Nature Reviews Genetics |
| Volume: | 8 |
| Issue: | 10 |
| ISSN: | 1471-0056 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-10-01 |
| Start Page: | 776 |
| End Page: | 790 |
| Language: | English |
| DOI: | 10.1038/nrg2172 |
| PUBMED: | 17846637 |
| PROVIDER: | scopus |
| PMCID: | PMC4689321 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 85" - "Export Date: 17 November 2011" - "CODEN: NRGAA" - "Source: Scopus" |
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