Ribozymes, riboswitches and beyond: Regulation of gene expression without proteins Journal Article


Authors: Serganov, A.; Patel, D. J.
Article Title: Ribozymes, riboswitches and beyond: Regulation of gene expression without proteins
Abstract: Although various functions of RNA are carried out in conjunction with proteins, some catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little or no assistance from proteins. Furthermore, the discovery of metabolite-sensing riboswitches and other types of RNA sensors has revealed RNA-based mechanisms that cells use to regulate gene expression in response to internal and external changes. Structural studies have shown how these RNAs can carry out a range of functions. In addition, the contribution of ribozymes and riboswitches to gene expression is being revealed as far more widespread than was previously appreciated. These findings have implications for understanding how cellular functions might have evolved from RNA-based origins. © 2007 Nature Publishing Group.
Keywords: review; nonhuman; binding affinity; animals; cell function; gene expression; gene function; evolution; structure activity relation; structure-activity relationship; evolution, molecular; rna; gene expression regulation; gene control; models, molecular; thermodynamics; binding sites; catalysis; nucleic acid conformation; protein folding; structure analysis; temperature measurement; catalytic domain; bacterium; rna splicing; regulatory sequences, ribonucleic acid; riboswitch; sensor; ribozyme; rna, catalytic
Journal Title: Nature Reviews Genetics
Volume: 8
Issue: 10
ISSN: 1471-0056
Publisher: Nature Publishing Group  
Date Published: 2007-10-01
Start Page: 776
End Page: 790
Language: English
DOI: 10.1038/nrg2172
PUBMED: 17846637
PROVIDER: scopus
PMCID: PMC4689321
DOI/URL:
Notes: --- - "Cited By (since 1996): 85" - "Export Date: 17 November 2011" - "CODEN: NRGAA" - "Source: Scopus"
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  1. Dinshaw J Patel
    478 Patel