The successful use of parenteral methadone in a patient with a prolonged QTc interval Journal Article
| Authors: | Sekine, R.; Obbens, E. A. M. T.; Coyle, N.; Inturrisi, C. E. |
| Article Title: | The successful use of parenteral methadone in a patient with a prolonged QTc interval |
| Abstract: | Recent case reports have raised concerns about the potential for methadone to prolong the QTc interval (QT corrected for heart rate) and predispose patients to torsade de pointes (TdP), a life-threatening arrhythmia. We present a case report that describes the successful use of parenteral and oral methadone in a patient with uncontrolled cancer pain and a history of QTc prolongation. We describe an approach to the use of methadone in this patient and review both case reports and recent prospective studies that have evaluated the risk of TdP and the long-term outcome with respect to the development of TdP in patients receiving methadone for chronic pain or addiction. © 2007 U.S. Cancer Pain Relief Committee. |
| Keywords: | adult; middle aged; major clinical study; case report; interferon; advanced cancer; hypertension; risk benefit analysis; palliative care; qt prolongation; steroid; cancer pain; kidney carcinoma; kidney neoplasms; high risk patient; backache; drug dose escalation; carcinoma, renal cell; add on therapy; cardiotoxicity; chronic pain; methadone; morphine; drug dose titration; heart arrhythmia; analgesics, opioid; anticonvulsive agent; disease predisposition; decision making; hydromorphone; analgesia; pain assessment; electrocardiogram; infusions, parenteral; spine metastasis; pain, intractable; gabapentin; oxycodone; opiate addiction; torsade des pointes; qt interval; prolonged qtc interval; torsade de pointes (tdp); chlorbutol; methadone treatment; long qt syndrome |
| Journal Title: | Journal of Pain and Symptom Management |
| Volume: | 34 |
| Issue: | 5 |
| ISSN: | 0885-3924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-11-01 |
| Start Page: | 566 |
| End Page: | 569 |
| Language: | English |
| DOI: | 10.1016/j.jpainsymman.2007.05.001 |
| PUBMED: | 17616330 |
| PROVIDER: | scopus |
| PMCID: | PMC2111130 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 7" - "Export Date: 17 November 2011" - "CODEN: JPSME" - "Source: Scopus" |
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