Immune-related cutaneous adverse events due to checkpoint inhibitors Review
| Authors: | Wang, E.; Kraehenbuehl, L.; Ketosugbo, K.; Kern, J. A.; Lacouture, M. E.; Leung, D. Y. M. |
| Review Title: | Immune-related cutaneous adverse events due to checkpoint inhibitors |
| Abstract: | Objective: To familiarize the reader with the most common cutaneous adverse events with immune checkpoint inhibitors (CPIs) and their grading and treatment. Data Sources: Recent research articles, relevant review articles, and case series/reports in English from the PubMed database mostly, from 2010 onward. Study Selections: Most data are from retrospective studies and case series. Older studies regarding the mechanism were included if they were of particular importance. Results: An understanding of this review should enable the reader to identify specific skin disorders in patients receiving immune CPIs, grade the adverse event, and be able to treat or refer the patient as needed. Conclusion: Allergists/immunologists need to be familiar with these immune-related cutaneous adverse events because their incidence will increase with the ever-expanding use of CPIs and, in particular, because patients will certainly continue to be referred suspecting drug allergies. © 2021 American College of Allergy, Asthma & Immunology |
| Keywords: | antibiotic agent; prednisone; review; dose response; drug withdrawal; skin toxicity; pathophysiology; methotrexate; rituximab; t lymphocyte; ipilimumab; cancer immunotherapy; melanoma; multiple cycle treatment; skin biopsy; lung cancer; immunoglobulin; steroid; psoriasis; pruritus; rash; maculopapular rash; t lymphocyte receptor; graft versus host reaction; antidepressant agent; methylprednisolone; skin disease; hydrocortisone; lymphocytic infiltration; corticosteroid; cytotoxic t lymphocyte antigen 4; doxycycline; alopecia; retinoid; biological product; antihistaminic agent; lichenoid eruption; stevens johnson syndrome; toxic epidermal necrolysis; measles like rash; gabapentin; triamcinolone; programmed death 1 ligand 1; programmed death 1 receptor; non small cell lung cancer; metastatic melanoma; pregabalin; melanoma vaccine; depigmentation; blister; vitiligo; eosinophil count; etretin; diphencyprone; desonide; bullous skin disease; mometasone furoate; oral mucosal disease; betamethasone dipropionate; immune checkpoint inhibitor; neurokinin 1 receptor antagonist; nivolumab; mouth lesion; human; priority journal; pembrolizumab; colecalciferol derivative; omalizumab; bullous pemphigoid; secukinumab; 4 aminobutyric acid derivative; dress syndrome; mucous membrane pemphigoid |
| Journal Title: | Annals of Allergy, Asthma & Immunology |
| Volume: | 126 |
| Issue: | 6 |
| ISSN: | 1081-1206 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-06-01 |
| Start Page: | 613 |
| End Page: | 622 |
| Language: | English |
| DOI: | 10.1016/j.anai.2021.02.009 |
| PUBMED: | 33609771 |
| PROVIDER: | scopus |
| PMCID: | PMC8165024 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 July 2021 -- Source: Scopus |
