Role of the chromobox protein CBX7 in lymphomagenesis Journal Article
| Authors: | Scott, C. L.; Gil, J.; Hernando, E.; Teruya-Feldstein, J.; Narita, M.; Martinez, D.; Visakorpi, T.; Mu, D.; Cordon-Cardo, C.; Peters, G.; Beach, D.; Lowe, S. W. |
| Article Title: | Role of the chromobox protein CBX7 in lymphomagenesis |
| Abstract: | Chromobox 7 (CBX7) is a chromobox family protein and a component of the Polycomb repressive complex 1 (PRC1) that extends the lifespan of cultured epithelial cells and can act independently of BMI-1 to repress the INK4a/ARF tumor suppressor locus. To determine whether CBX7 might be oncogenic, we examined its expression pattern in a range of normal human tissues and tumor samples. CBX7 was expressed at high levels in germinal center lymphocytes and germinal center-derived follicular lymphomas, where elevated expression correlated with high c-Myc expression and a more advanced tumor grade. By targeting Cbx7 expression to the lymphoid compartment in mice, we showed that Cbx7 can initiate T cell lymphomagenesis and cooperate with c-Myc to produce highly aggressive B cell lymphomas. Furthermore, Cbx7 repressed transcription from the Ink4a/Arf locus and acted epistatically to the Arf-p53 pathway during tumorigenesis. These data identify CBX7 as a chromobox protein causally linked to cancer development and may help explain the low frequency of INK4a/ ARF mutations observed in human follicular lymphoma. © 2007 by The National Academy of Sciences of the USA. |
| Keywords: | controlled study; human tissue; protein expression; unclassified drug; human cell; genetics; mutation; histopathology; nonhuman; neoplasm; neoplasms; t lymphocyte; t-lymphocytes; mouse; animal; cytology; metabolism; animals; mice; animal tissue; mus; nuclear protein; protein; gene locus; genetic transcription; protein p53; physiology; carcinogenesis; nuclear proteins; oncogene; germinal center; t cell lymphoma; chemistry; transcription regulation; myc protein; gene repression; western blotting; lymphoma; epithelium cell; epithelial cells; tumor suppressor protein p53; immunophenotyping; real time polymerase chain reaction; heterozygosity loss; cyclin-dependent kinase inhibitor p16; loss of heterozygosity; proto-oncogene proteins c-myc; lymphocyte; repressor protein; repressor proteins; follicular lymphoma; p53; polycomb; polycomb group proteins; protein p16ink4a; ink4a-arf; protein cbx7; cbx7 protein, human; cbx7 protein, mouse |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 104 |
| Issue: | 13 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2007-03-27 |
| Start Page: | 5389 |
| End Page: | 5394 |
| Language: | English |
| DOI: | 10.1073/pnas.0608721104 |
| PUBMED: | 17374722 |
| PROVIDER: | scopus |
| PMCID: | PMC1828941 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 17 November 2011" - "CODEN: PNASA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
22Hernando -
297Feldstein -
612
Cordon-Cardo
Related MSK Work