The theory of APL revisited Journal Article
| Authors: | Scaglioni, P. P.; Pandolfi, P. P. |
| Article Title: | The theory of APL revisited |
| Abstract: | Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in themajority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant chimeric proteins that exert critical oncogenic functions. Here we will integrate some of the most recent findings in APL research in a unified model and discuss some of the outstanding questions that remain to be addressed. © Springer-Verlag 2007. |
| Keywords: | signal transduction; unclassified drug; oncoprotein; gene translocation; genetics; review; nonhuman; pathophysiology; mutant protein; mouse; animal; metabolism; animals; mice; cell survival; bone marrow; cancer research; carcinogenesis; haplotype; cell transformation, neoplastic; disease model; cancer genetics; chromosome aberration; oncogene; leukemia, promyelocytic, acute; hybrid protein; cell transformation; genomic instability; leukemogenesis; hematopoietic system; promyelocytic leukemia; oncogene proteins, fusion; x chromosome; translocation, genetic; cross reaction; disease models, animal; malignant transformation; chimeric protein; promyelocytic leukemia protein; retinoic acid receptor alpha; retinoic acid receptor; protein plzf; stat5b protein; receptors, retinoic acid; retinoid x receptor; chromosome translocation 17; protein npm; protein numa |
| Journal Title: | Current Topics in Microbiology and Immunology |
| Volume: | 313 |
| ISSN: | 0070-217X |
| Publisher: | Springer Verlag |
| Date Published: | 2007-01-01 |
| Start Page: | 85 |
| End Page: | 100 |
| Language: | English |
| PUBMED: | 17217040 |
| PROVIDER: | scopus |
| DOI: | 10.1007/978-3-540-34594-7_6 |
| DOI/URL: | |
| Notes: | --- Chapter in "Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy" (ISBN: 978-3-540-34592-3) - "Cited By (since 1996): 21" - "Export Date: 17 November 2011" - "CODEN: CTMIA" - "Source: Scopus" |
