Multivalent engagement of chromatin modifications by linked binding modules Journal Article
| Authors: | Ruthenburg, A. J.; Li, H.; Patel, D. J.; David Allis, C. |
| Article Title: | Multivalent engagement of chromatin modifications by linked binding modules |
| Abstract: | Various chemical modifications on histones and regions of associated DNA play crucial roles in genome management by binding specific factors that, in turn, serve to alter the structural properties of chromatin. These so-called effector proteins have typically been studied with the biochemist's paring knife - the capacity to recognize specific chromatin modifications has been mapped to an increasing number of domains that frequently appear in the nuclear subset of the proteome, often present in large, multisubunit complexes that bristle with modification-dependent binding potential. We propose that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions. © 2007 Nature Publishing Group. |
| Keywords: | methylation; review; mass spectrometry; animals; protein protein interaction; protein binding; dna; epigenetics; histone; chromatin; chromatin immunoprecipitation; thermodynamics; protein structure; histones; chromatin assembly and disassembly; protein modification; nucleosome; histone code |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 8 |
| Issue: | 12 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-12-01 |
| Start Page: | 983 |
| End Page: | 994 |
| Language: | English |
| DOI: | 10.1038/nrm2298 |
| PUBMED: | 18037899 |
| PROVIDER: | scopus |
| PMCID: | PMC4690530 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 255" - "Export Date: 17 November 2011" - "CODEN: NRMCB" - "Source: Scopus" |
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