Long-term outcomes after surgical resection of pancreatic metastases from renal clear-cell carcinoma Journal Article
| Authors: | Malleo, G.; Salvia, R.; Maggino, L.; Marchegiani, G.; D'Angelica, M.; DeMatteo, R.; Kingham, P.; Pulvirenti, A.; Sereni, E.; Jarnagin, W. R.; Bassi, C.; Allen, P. J.; Butturini, G. |
| Article Title: | Long-term outcomes after surgical resection of pancreatic metastases from renal clear-cell carcinoma |
| Abstract: | Background Pancreatic metastases (PM) from renal cell carcinoma (RCC) are uncommon. We herein describe the long-term outcomes associated with pancreatectomy at two academic institutions, with a specific focus on 10-year survival. Methods This investigation was limited to patients undergoing pancreatectomy for PM between 2000 and 2008 at the University of Verona and Memorial Sloan Kettering Cancer Center, allowing a potential for 10 years of surveillance. The probabilities of further RCC recurrence and RCC-related death were estimated using a competing risk analysis (method of Fine and Gray) to account for patients who died of other causes during follow-up. Results The study population consisted of 69 patients, mostly with isolated metachronous PM (77%). The median interval from nephrectomy to pancreatic metastasectomy was 109 months, whereas the median post-pancreatectomy follow-up was 141 months. The 10-year cumulative incidence of new RCC recurrence was 62.7%. In the adjusted analysis, the relative risk of repeated recurrence was significantly higher in PM synchronous to the primary RCC (sHR = 1.27) and in patients receiving extended pancreatectomy (sHR = 3.05). The 10-year cumulative incidence of disease-specific death was 25.5%. The only variable with an influence on disease-specific death was the recurrence-free interval following metastasectomy (sHR = 0.98). In patients with repeated recurrence, the 10-year cumulative incidence of RCC-related death was 35.4%. Conclusion In a selected group of patients followed for a median of 141 months and mostly with isolated metachronous PM, resection was associated with a high possibility of long-term disease control in surgically fit patients with metastases confined to the pancreas. |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 28 |
| Issue: | 6 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2021-06-01 |
| Start Page: | 3100 |
| End Page: | 3108 |
| Language: | English |
| ACCESSION: | WOS:000617098400001 |
| DOI: | 10.1245/s10434-021-09649-w |
| PROVIDER: | wos |
| PMCID: | PMC8119267 |
| PUBMED: | 33575870 |
| Notes: | Article -- Source: Wos |
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903Jarnagin -
777D'Angelica -
609Kingham -
30Pulvirenti
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