Formulation of electrospun Mg-FA/poly (ε-caprolactone) nanocomposite to adjust bioactivity, biodegradability, and cellular interactions Journal Article
| Authors: | Fereshteh, Z.; Fathi, M.; Kargozar, S.; Samadikuchaksaraei, A. |
| Article Title: | Formulation of electrospun Mg-FA/poly (ε-caprolactone) nanocomposite to adjust bioactivity, biodegradability, and cellular interactions |
| Abstract: | Adjusting the biological properties of scaffolds is one of the most challenging issues in tissue engineering. Here, we focus on formulating a nanocomposite with tunability for bioactivity, biodegradability, and cellular interactions by using different nanoparticles composition and concentration. Here, after optimizing Mg+2 ions concentration in fluorapatite nanoparticles (Mg-FA NPs), we probed the influence of Mg-FA NPs on the biological properties of the electrospun Mg-FA/poly (ε-caprolactone). Increasing Mg-FA nanoparticles up to 15 wt% in the composite could enhance the bioactivity from 0.02 wt% in the pure PCL scaffold up to 3 wt% (150 times more) by gaining weight after 28-day incubation in simulated body fluid (SBF) at 37°C. In the same order, the biodegradation of scaffolds accelerated from 3.1 wt% to 34.6 wt% (11 times more). The cell attachment assays, using MG-63, showed that the presence of Mg-FA NPs plays a crucial role to attach cells on the surface by improving wettability as well as biocompatibility. Also, the Mg-FA NPs encouraged MG-63 cells to proliferate on/inside the scaffolds and generate 3D cell networks. © 2021 John Wiley & Sons Ltd. |
| Keywords: | cytology; bioactivity; biocompatibility; nanoparticles; body fluids; tissue engineering; cells; biodegradation; biodegradability; biological properties; nanocomposites; cellular interaction; scaffolds (biology); electrospun nanocomposite; mg-doped fluorapatite nanoparticles; poly (ε-caprolactone); cell attachment assays; cell network; electrospuns; fluorapatites; simulated body fluids; tunabilities |
| Journal Title: | Polymers for Advanced Technologies |
| Volume: | 32 |
| Issue: | 6 |
| ISSN: | 1042-7147 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2021-06-01 |
| Start Page: | 2597 |
| End Page: | 2608 |
| Language: | English |
| DOI: | 10.1002/pat.5291 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2021 -- Source: Scopus |
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