18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases Journal Article
| Authors: | Riedl, C. C.; Akhurst, T.; Larson, S.; Stanziale, S. F.; Tuorto, S.; Bhargava, A.; Hricak, H.; Klimstra, D.; Fong, Y. |
| Article Title: | 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases |
| Abstract: | 18F-FDG PET has proven invaluable in the staging of patients with metastatic colorectal cancer. The aim of the current study was to determine whether this biologic scan would correlate with other cellular characteristics and the clinical behavior of tumors. Methods: Ninety patients with resectable colorectal cancer metastatic to the liver underwent 18F-FDG PET before hepatectomy. At surgery, tumors were harvested and prepared for assessment by histology and immunohistochemistry. Expression of Ki67 (a marker for cell proliferation), GLUT1 and GLUT3 (markers for glucose transportation), p53 and p27 (markers for cell cycle control), and BCL-2 (a marker for apoptosis) was assessed by a pathologist who was unaware of the PET results and the clinical outcome. Patients were followed to determine outcome. Survival analysis was performed comparing patient outcome in groups segregated according to standardized uptake values (SUVs) greater or less than 5, 7, or 10. Results: Maximum SUV correlated with GLUT1 (P = 0.03), Ki67 (P = 0.026), and p53 (P = 0.024) but did not correlate with p27, BCL-2, or GLUT3. Survival was significantly longer for patients with a low SUV than for patients with a high SUV, with P values of 0.014, 0.025, and 0.0095 for SUV cutoffs of 5, 7, and 10, respectively. Conclusion: 18F-FDG PET is a biologic scan that predicts prognosis in patients with metastatic colorectal cancer. It is uncertain if this ability is due to cellular glucose metabolism or to a correlation with other cellular characteristics of aggressive tumors. Copyright © 2007 by the Society of Nuclear Medicine, Inc. |
| Keywords: | immunohistochemistry; adult; cancer survival; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; middle aged; survival rate; major clinical study; clinical trial; mortality; liver neoplasms; united states; positron emission tomography; methodology; sensitivity and specificity; radiopharmaceuticals; colorectal cancer; ki 67 antigen; reproducibility; reproducibility of results; protein bcl 2; metastasis; statistics; incidence; tumor markers, biological; risk factors; protein p53; tumor marker; risk factor; cancer mortality; risk assessment; colorectal neoplasms; liver metastasis; blood; diagnostic agent; colorectal tumor; liver tumor; protein p27; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; scintiscanning; outcome; liver resection; hepatectomy; new york; pet; glucose transporter 3; hepatic metastases; glucose transporter 1; 18f-fdg; prognostic variables; suv |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 48 |
| Issue: | 5 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2007-05-01 |
| Start Page: | 771 |
| End Page: | 775 |
| Language: | English |
| DOI: | 10.2967/jnumed.106.037291 |
| PUBMED: | 17475966 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 30" - "Export Date: 17 November 2011" - "CODEN: JNMEA" - "Source: Scopus" |
