Prognostic value of the Memorial Sloan Kettering Prognostic Score in metastatic pancreatic adenocarcinoma Journal Article
| Authors: | Lebenthal, J. M.; Zheng, J.; Glare, P. A.; O’Reilly, E. M.; Yang, A. C.; Epstein, A. S. |
| Article Title: | Prognostic value of the Memorial Sloan Kettering Prognostic Score in metastatic pancreatic adenocarcinoma |
| Abstract: | Background: The Memorial Sloan Kettering Prognostic Score (MPS), a composite of the neutrophil-lymphocyte ratio (NLR) and albumin, is an objective prognostic tool created as a more readily available alternative to the Glasgow Prognostic Score. A prior analysis of patients with metastatic pancreatic adenocarcinoma (mPDAC) suggested that the MPS may predict survival, although it did not control for clinically relevant factors. Methods: MPS scores were calculated for patients with mPDAC treated at Memorial Sloan Kettering Cancer Center from January 1, 2011, to December 31, 2014. An MPS scale of 0 to 2 was used: 0 for an albumin level ≥ 4 g/dL and an NLR ≤ 4 g/dL, 1 for either an albumin level < 4 g/dL or an NLR > 4 g/dL, and 2 for an albumin level < 4 g/dL and an NLR > 4 g/dL. Performance status, antineoplastic therapy, presence of thromboembolism (TE), radiation therapy, and metastatic sites were also analyzed. The associations with overall survival were examined with time-dependent Cox proportional hazards regression analyses. Results: A multivariate model revealed that higher MPS scores at diagnosis (hazard ratio for MPS of 2 vs MPS of 0, 1.41; 95% confidence interval, 1.13-1.76), liver metastases, radiation therapy, hospital admissions, TE, and performance status were associated with worse overall survival. The median overall survival for patients with MPS scores of 0, 1, and 2 were 12.9, 9.0, and 5.4 months, respectively. Conclusions: The MPS, an easily calculated composite of the NLR and albumin, is an objective tool that may predict survival in mPDAC independently of performance status, disease characteristics, and cancer therapy. Lay Summary: The Memorial Sloan Kettering Prognostic Score (MPS) is a new scoring system that incorporates markers of inflammation found in individuals' blood at the diagnosis of metastatic pancreatic cancer. Data suggest that the MPS may help to determine prognosis. © 2021 American Cancer Society |
| Keywords: | adult; controlled study; aged; human cell; major clinical study; overall survival; erlotinib; fluorouracil; gemcitabine; paclitaxel; cancer radiotherapy; pancreas cancer; cohort analysis; retrospective study; irinotecan; liver metastasis; albumin; thromboembolism; folinic acid; pancreas adenocarcinoma; neutrophils; hospital admission; mitomycin; oxaliplatin; lymphocytes; fluoropyrimidine; functional status; predictive value; cancer prognosis; prognosis; human; male; female; priority journal; article; prognostic assessment; neutrophil lymphocyte ratio; albumin level; memorial sloan kettering prognostic score |
| Journal Title: | Cancer |
| Volume: | 127 |
| Issue: | 10 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2021-05-15 |
| Start Page: | 1568 |
| End Page: | 1575 |
| Language: | English |
| DOI: | 10.1002/cncr.33420 |
| PUBMED: | 33471374 |
| PROVIDER: | scopus |
| PMCID: | PMC8084949 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 June 2021 -- Source: Scopus |
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