Polo kinase and cytokinesis initiation in mammalian cells: Harnessing the awesome power of chemical genetics Journal Article
| Authors: | Randall, C. L.; Burkard, M. E.; Jallepalli, P. V. |
| Article Title: | Polo kinase and cytokinesis initiation in mammalian cells: Harnessing the awesome power of chemical genetics |
| Abstract: | The last decade has brought rapid advances in our knowledge of the human genome, as well as increasingly sophisticated methods to analyze how each of ∼30,000 genes within it contribute to cellular, tissue, and organismal function. Here, we review this technological revolution in the context of Polo-like kinase 1 (Plk1), which has emerged as a central regulator of multiple processes fundamental to cell division. In particular, we highlight similarities and differences when Plk1 function is probed through various methods, including novel chemical inhibitors, and how our understanding of Plk1's role in mitosis and cell division has been enhanced as a consequence. ©2007 Landes Bioscience. |
| Keywords: | unclassified drug; gene deletion; proto-oncogene proteins; review; nonhuman; antineoplastic agent; mitosis; mammalia; animals; cell cycle proteins; cell division; drug inhibition; rna interference; inhibitor; protein-serine-threonine kinases; anaphase; chemical genetics; genome; cell cycle m phase; down regulation; antibodies; yeast; enzyme kinetics; polo like kinase 2; isoenzymes; immunofluorescence microscopy; cytokinesis; mammal cell; microinjection; rhoa; carrier proteins and binding proteins; polo like kinase 3; polo like kinase; Plk1; ect2; bi 2536; bto-1; protein cdc5; protein cdcl |
| Journal Title: | Cell Cycle |
| Volume: | 6 |
| Issue: | 14 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2007-07-15 |
| Start Page: | 1713 |
| End Page: | 1717 |
| Language: | English |
| PUBMED: | 17630508 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "Source: Scopus" |
