Prognostic significance of p27Kip1 expression in bladder cancer Journal Article
| Authors: | Rabbani, F.; Koppie, T. M.; Charytonowicz, E.; Drobnjak, M.; Bochner, B. H.; Cordon-Cardo, C. |
| Article Title: | Prognostic significance of p27Kip1 expression in bladder cancer |
| Abstract: | OBJECTIVE: To define the prognostic significance of p27Kip1 expression in bladder cancer for overall, disease-specific, metastasis-free and pelvic recurrence-free survival, and to identify clinical and pathological correlates of p27Kip1 immunophenotypes. PATIENTS AND METHODS: Tumour samples from 128 evaluable patients with bladder cancer were assessed by immunohistochemistry for p27Kip1 and E2F-1 expression. Immunoreactivity of p27Kip1 was correlated with clinicopathological variables, E2F-1 immunoreactivity, and outcome. Multivariate analysis was used to assess predictors of outcome. The median follow-up was 30.9 months overall and 105.7 months in the 32 patients alive at the last follow-up. RESULTS: The fraction of tumour cells with p27Kip1 nuclear immunoreactivity was <5% in 15, 5-25% in 30, 25-50% in 19, 50-75% in 51, and ≥75% in 13 patients. High-grade tumours and those with lower E2F-1 nuclear reactivity had a lower mean percentage p27Kip1 reactivity (P = 0.047 and 0.011, respectively). On multivariate analysis, the percentage p27Kip1 reactivity was a significant independent predictor of pelvic recurrence (P = 0.017), progression to metastases (P = 0.046), death from disease (P = 0.008), and death from any cause (P = 0.017), with a low expression portending a worse prognosis. Suspicion of vascular invasion was a significant independent predictor of progression to metastases (P = 0.002), death from disease, and death from any cause (both P < 0.001). Lymph node involvement was a significant independent predictor of progression to metastases (P = 0.006). CONCLUSIONS: Low expression of p27Kip1 was a significant independent predictor of pelvic recurrence, progression to metastasis, death from disease and death from any cause, in patients with bladder cancer. © 2007 THE AUTHORS. |
| Keywords: | immunohistochemistry; cancer survival; human tissue; major clinical study; cancer patient; outcome assessment; follow-up studies; lymph node metastasis; cancer grading; neoplasm recurrence, local; immunoreactivity; bladder cancer; urinary bladder neoplasms; cancer mortality; cancer invasion; statistical significance; inhibitor of apoptosis protein 1; cyclin-dependent kinase inhibitor p27; neoplasm metastasis; cell fractionation; multivariate analysis; bladder neoplasms; transcription factor e2f1; p27kip1; e2f1 transcription factor; tumour suppressor gene |
| Journal Title: | BJU International |
| Volume: | 100 |
| Issue: | 2 |
| ISSN: | 1464-4096 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2007-08-01 |
| Start Page: | 259 |
| End Page: | 263 |
| Language: | English |
| DOI: | 10.1111/j.1464-410X.2007.06927.x |
| PUBMED: | 17555476 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 17 November 2011" - "CODEN: BJINF" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
24Koppie -
84
Rabbani -
612
Cordon-Cardo -
468Bochner -
61Drobnjak
Related MSK Work