Tensin relief facilitates migration Journal Article

  


Authors: Pylayeva, Y.; Giancotti, F. G.
Article Title: Tensin relief facilitates migration
Abstract: The molecular mechanisms through which the epidermal growth factor receptor (EGFR) promotes normal cell migration and carcinoma invasion are incompletely understood. A new study reveals that EGFR induces a switch in expression from tensin to its endogenous inhibitor cten (C-terminal tensin-like protein), alleviating integrin linkage to the cytoskeleton. Analysis of clinical samples suggests that this may be important for breast cancer invasion.
Keywords: protein expression; unclassified drug; protein function; animals; metastasis; breast cancer; epidermal growth factor receptor; cell protein; receptor, epidermal growth factor; breast neoplasms; microfilament proteins; cancer invasion; molecular mechanics; regulatory mechanism; cancer cell; carcinoma; cell migration; cell movement; neoplasm invasiveness; tensin; cell adhesion; cytoskeleton; polarization; integrins
Journal Title: Nature Cell Biology
Volume: 9
Issue: 8
ISSN: 1465-7392
Publisher: Nature Publishing Group  
Date Published: 2007-08-01
Start Page: 877
End Page: 879
Language: English
DOI: 10.1038/ncb0807-877
PUBMED: 17671456
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-34547596641&partnerID=40&md5=1845615ea917e02b7cf9560e1dbc03c2
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: NCBIF" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Yuliya Pylayeva
    6 Pylayeva
  2. Filippo G Giancotti
    91 Giancotti
Related MSK Work