Mitoxantrone in secondary progressive multiple sclerosis: A review of toxicity in 41 patients Journal Article
| Authors: | Peak, S.; Tsao-Wei, D. D.; Chamberlain, M. C. |
| Article Title: | Mitoxantrone in secondary progressive multiple sclerosis: A review of toxicity in 41 patients |
| Abstract: | Aims: The primary objective of this study was to summarize the toxicity of mitoxantrone treatment of secondary progressive multiple sclerosis (SPMS), with particular focus on cardiotoxicity, hematological and nonhematological toxicities. Methods: A total of 41 patients with SPMS were treated with mitoxantrone and their charts retrospectively reviewed for efficacy of treatment and frequency of toxicity. Results: Mitoxantrone toxicity was common but treatable, and was effective in achieving disease stabilization in the majority of patients. Conclusions: When monitored appropriately, mitoxantrone is safe and effective in the treatment of SPMS. © 2007 Future Medicine Ltd. |
| Keywords: | adult; clinical article; controlled study; treatment outcome; aged; antibiotic agent; neutropenia; review; drug efficacy; drug safety; side effect; multiple cycle treatment; bone marrow suppression; heart disease; cyclophosphamide; patient monitoring; medical record review; febrile neutropenia; injection site reaction; mitoxantrone; disease duration; staphylococcus infection; echocardiography; beta1a interferon; multiple sclerosis; heart left ventricle ejection fraction; convalescence; granulocyte colony stimulating factor; congestive heart failure; hematologic disease; skin transplantation; glatiramer; t lymphocyte antibody; expanded disability status scale; secondary progressive multiple sclerosis; interferon beta serine; injection site extravasation; perianal abscess |
| Journal Title: | Therapy |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 1475-0708 |
| Publisher: | Future Medicine |
| Date Published: | 2007-01-01 |
| Start Page: | 55 |
| End Page: | 58 |
| Language: | English |
| DOI: | 10.2217/14750708.4.1.55 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "Source: Scopus" |
