Utility of bronchoscopy with bronchoalveolar lavage among hematologic transplant recipients in the era of noninvasive testing Journal Article

   


Authors: Feinstein, M. B.; Habtes, I.; Giralt, S.; Stover, D. E.
Article Title: Utility of bronchoscopy with bronchoalveolar lavage among hematologic transplant recipients in the era of noninvasive testing
Abstract: Background: Pulmonary complications are common among hematologic stem cell transplant (HSCT) recipients. Their evaluation can be pursued through bronchoscopy with bronchoalveolar lavage (BAL) and a variety of available noninvasive studies, which include newer molecular markers for detecting a variety of infectious agents. Objective: The objective of this study is to evaluate the diagnostic yield of BAL among HSCT patients relative to the yield of noninvasive testing. Method: This is a retrospective analysis of HSCT recipients who underwent both BAL and noninvasive testing at a cancer center in 2013 and 2014. Results: There were 210 diagnostic results among 98 HSCT recipients. There were 84 unique findings on noninvasive testing that were not evident on BAL, and 36 unique findings on BAL that were not evident on noninvasive testing. Noninvasive testing tended to yield bacterial and viral infections more commonly, while BAL yielded mycobacterial isolates more commonly. Conclusion: While both noninvasive testing and BAL are helpful in this population, each appeared more precise than the other with individual lung diseases. Bronchoscopy with BAL and noninvasive testing should be considered complementary strategies in the workup of pulmonary complications among HSCT patients. © 2021 S. Karger AG, Basel. Copyright: All rights reserved.
Keywords: transplantation; pneumonia; bronchoalveolar lavage; allogeneic; autologous
Journal Title: Respiration
Volume: 100
Issue: 4
ISSN: 0025-7931
Publisher: S. Karger AG  
Date Published: 2021-04-01
Start Page: 339
End Page: 346
Language: English
DOI: 10.1159/000512376
PUBMED: 33626524
PROVIDER: scopus
PMCID: PMC8035270
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101765927&doi=10.1159%2f000512376&partnerID=40&md5=808e6c06db73d3269c4d11e9fa605fc8
Notes: Article -- Export Date: 3 May 2021 -- Source: Scopus
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MSK Authors
  1. Marc B Feinstein
    39 Feinstein
  2. Sergio Andres Giralt
    919 Giralt
  3. Diane E Stover-Pepe
    106 Stover-Pepe
  4. Imnett Y Habtes
    3 Habtes
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