Targeted drug delivery strategies for precision medicines Review

Authors: Manzari, M. T.; Shamay, Y.; Kiguchi, H.; Rosen, N.; Scaltriti, M.; Heller, D. A.
Review Title: Targeted drug delivery strategies for precision medicines
Abstract: Progress in the field of precision medicine has changed the landscape of cancer therapy. Precision medicine is propelled by technologies that enable molecular profiling, genomic analysis and optimized drug design to tailor treatments for individual patients. Although precision medicines have resulted in some clinical successes, the use of many potential therapeutics has been hindered by pharmacological issues, including toxicities and drug resistance. Drug delivery materials and approaches have now advanced to a point where they can enable the modulation of a drug’s pharmacological parameters, without compromising the desired effect on molecular targets. Specifically, they can modulate a drug’s pharmacokinetics, stability, absorption and exposure to tumours and healthy tissues, and facilitate the administration of synergistic drug combinations. This Review highlights recent progress in precision therapeutics and drug delivery, and identifies opportunities for strategies to improve the therapeutic index of cancer drugs and, consequently, clinical outcomes. © 2021, Springer Nature Limited.
Keywords: drug combinations; diseases; molecular profiling; personalized medicine; molecular targets; clinical outcome; targeted drug delivery; therapeutic index; genomic analysis; controlled drug delivery; drug delivery materials; drug delivery strategies
Journal Title: Nature Reviews Materials
Volume: 6
Issue: 4
ISSN: 2058-8437
Publisher: Nature Publishing Group  
Date Published: 2021-04-01
Start Page: 351
End Page: 370
Language: English
DOI: 10.1038/s41578-020-00269-6
PROVIDER: scopus
Notes: Review -- Export Date: 3 May 2021 -- Source: Scopus
Citation Impact
MSK Authors
  1. Neal Rosen
    400 Rosen
  2. Daniel Alan Heller
    74 Heller
  3. Maurizio Scaltriti
    161 Scaltriti