Liposomal bupivacaine versus bupivacaine hydrochloride for intercostal nerve blockade in minimally invasive thoracic surgery Journal Article
| Authors: | Pedoto, A.; Noel, J.; Park, B. J.; Amar, D. |
| Article Title: | Liposomal bupivacaine versus bupivacaine hydrochloride for intercostal nerve blockade in minimally invasive thoracic surgery |
| Abstract: | Objectives: The objective of this study was to compare the effects of liposomal bupivacaine (Lipo-B) and bupivacaine hydrochloride (B-HCl), in the presence of multimodal analgesia, on postoperative analgesia and opioid consumption in minimally invasive thoracic surgery (MITS) lobectomy. Design: Retrospective observational cohort study. Setting: Tertiary care cancer center. Participants: A total of 60 patients who underwent MITS lobectomy and received intercostal nerve blockade (ICNB) with either 0.66% Lipo-B (n = 29) or 0.5% B-HCl (n = 31). Interventions: All patients received intravenous patient-controlled analgesia for the first 12 hours postoperatively, followed by opioids and nonsteroidal anti-inflammatory drugs as needed. Measurements and Main Results: Perioperative opioid and nonopioid consumption and pain scores were compared between groups at 12-hour intervals for the first 72 hours. Between the two groups, there were no statistically significant differences in demographic characteristics, intraoperative (p = 0.46) and postoperative opioid consumption, Richmond Agitation-Sedation Scale scores and pain scores upon postanesthesia care unit arrival and after four hours, length of postanesthesia care unit stay (p = 0.84), or length of hospital stay (p = 0.55). Both groups received intra- and postoperative multimodal analgesia. Conclusions: In this cohort, no differences in opioid consumption or pain scores were observed in the immediate postoperative period following MITS lobectomy between patients given ICNB with Lipo-B and those given ICNB with B-HCl in the presence of multimodal analgesia. © 2020 Elsevier Inc. |
| Keywords: | acute pain; liposomal bupivacaine; intercostal nerve blockade; minimally invasive thoracic surgery |
| Journal Title: | Journal of Cardiothoracic and Vascular Anesthesia |
| Volume: | 35 |
| Issue: | 5 |
| ISSN: | 1053-0770 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-05-01 |
| Start Page: | 1393 |
| End Page: | 1398 |
| Language: | English |
| DOI: | 10.1053/j.jvca.2020.11.067 |
| PUBMED: | 33376072 |
| PROVIDER: | scopus |
| PMCID: | PMC9472479 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 May 2021 -- Source: Scopus |
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