Head and neck tumor control probability: Radiation dose-volume effects in stereotactic body radiation therapy for locally recurrent previously-irradiated head and neck cancer: Report of the AAPM Working Group Review
| Authors: | Vargo, J. A.; Moiseenko, V.; Grimm, J.; Caudell, J.; Clump, D. A.; Yorke, E.; Xue, J.; Vinogradskiy, Y.; Moros, E. G.; Mavroidis, P.; Jain, S.; El Naqa, I.; Marks, L. B.; Heron, D. E. |
| Review Title: | Head and neck tumor control probability: Radiation dose-volume effects in stereotactic body radiation therapy for locally recurrent previously-irradiated head and neck cancer: Report of the AAPM Working Group |
| Abstract: | Purpose: Stereotactic body radiation therapy (SBRT) has emerged as a viable reirradiation strategy for locally recurrent previously-irradiated head and neck cancer. Doses in the literature have varied, which challenges clinical application of SBRT as well as clinical trial design. Material & Methods: A working group was formed through the American Association of Physicists in Medicine to study tumor control probabilities for SBRT in head and neck cancer. We herein present a systematic review of the available literature addressing the dose/volume data for tumor control probability with SBRT in patients with locally recurrent previously-irradiated head and neck cancer. Dose–response models are generated that present tumor control probability as a function of dose. Results: Data from more than 300 cases in 8 publications suggest that there is a dose–response relationship, with superior local control and possibly improved overall survival for doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. Conclusion: Stereotactic body radiation therapy doses equivalent to 5-fraction doses of 40 to 50 Gy are suggested for retreatment. © 2018 Elsevier Inc. |
| Keywords: | radiotherapy; radiation effects; tumors; probability; stereotactic body radiation therapy; diseases; clinical application; head-and-neck cancer; medical applications; tumor control probability; dose-volume effects; clinical trial designs; dose response relationships; dose-response models |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 110 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-05-01 |
| Start Page: | 137 |
| End Page: | 146 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2018.01.044 |
| PUBMED: | 29477291 |
| PROVIDER: | scopus |
| PMCID: | PMC7294512 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 May 2021 -- Source: Scopus |
