Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma Journal Article
| Authors: | Askan, G.; Sahin, I. H.; Chou, J. F.; Yavas, A.; Capanu, M.; Iacobuzio-Donahue, C. A.; Basturk, O.; O’Reilly, E. M. |
| Article Title: | Pancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma |
| Abstract: | Background: Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ductal adenocarcinoma (PDAC) patients. Methods: PDAC patients who underwent surgical resection between 01/2012–06/2014 were identified. CD44 and ESA expression was assessed by immunohistochemistry. Stroma was classified as loose, moderate, and dense based on fibroblast content. Overall survival (OS) and relapse-free survival (RFS) were estimated using the Kaplan-Meier method and compared between subgroups by log-rank test. The association between PCSC markers and stroma type was assessed by Fisher’s exact test. Results: N = 93 PDAC patients were identified. The number of PDAC patients with dense, moderate density, and loose stroma was 11 (12%), 51 (54%), and 31 (33%) respectively. PDAC with CD44+/ESA− had highest rate of loose stroma (63%) followed by PDAC CD44+/ESA+ (50%), PDAC CD44−/ESA+ (35%), CD44−/ESA− (9%) (p = 0.0033). Conversely, lack of CD44 and ESA expression was associated with the highest rate of moderate and dense stroma (91% p = 0.0033). No local recurrence was observed in patients with dense stroma and 9 had distant recurrence. The highest rate of cumulative local recurrence was observed in patients with loose stroma. No statistically significant difference in RFS and OS was observed among subgroups (P = 0.089). Conclusions: These data indicate PCSCs may have an important role in stroma differentiation in PDAC. Our results further suggest that tumor stroma may influence the recurrence pattern in PDAC patients. © 2021, The Author(s). |
| Keywords: | pancreatic cancer; sonic hedgehog; tumor microenvironment; cancer stem cells; pancreatic ductal adenocarcinoma; recurrence pattern; cd44; tumor stroma; desmoplasia; esa |
| Journal Title: | BMC Cancer |
| Volume: | 21 |
| ISSN: | 1471-2407 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2021-04-09 |
| Start Page: | 385 |
| Language: | English |
| DOI: | 10.1186/s12885-021-08123-w |
| PUBMED: | 33836674 |
| PROVIDER: | scopus |
| PMCID: | PMC8034174 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 May 2021 -- Source: Scopus |
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