Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma Journal Article

  

Authors:	O'Connor, O. A.; Hamlin, P. A.; Portlock, C.; Moskowitz, C. H.; Noy, A.; Straus, D. J.; Macgregor-Cortelli, B.; Neylon, E.; Sarasohn, D.; Dumetrescu, O.; Mould, D. R.; Fleischer, M.; Zelenetz, A. D.; Sirotnak, F.; Horwitz, S.
Article Title:	Pralatrexate, a novel class of antifol with high affinity for the reduced folate carrier-type 1, produces marked complete and durable remissions in a diversity of chemotherapy refractory cases of T-cell lymphoma
Abstract:	T-cell lymphomas (TCLs) are characterised by poor responses to therapy with brief durations of remissions. An early phase study of pralatrexate has demonstrated dramatic activity in patients with relapsed/refractory disease. Of the first 20 lymphoma patients treated, 16 had B-cell lymphoma and four had refractory aggressive TCL. All four patients with TCL achieved a complete remission. Patients with B-cell lymphoma achieved stable disease at best. For each TCL patient, the response was more durable than their best response with chemotherapy. This early experience is the first to document this unique activity of pralatrexate in TCL. © 2007 The Authors.
Keywords:	adult; cancer chemotherapy; clinical article; controlled study; treatment outcome; aged; middle aged; treatment failure; unclassified drug; prednisone; drug tolerability; doxorubicin; antineoplastic agents; positron emission tomography; follow up; antineoplastic agent; carboplatin; computer assisted tomography; skin defect; etoposide; antineoplastic combined chemotherapy protocols; combination chemotherapy; cyclophosphamide; vincristine; ifosfamide; b cell lymphoma; lymphoma, b-cell; t cell lymphoma; lymphoma, t-cell; drug response; positron-emission tomography; folic acid antagonists; t-cell lymphoma; pralatrexate; aminopterin; antifolate; membrane transport proteins; reduced folate carrier
Journal Title:	British Journal of Haematology
Volume:	139
Issue:	3
ISSN:	0007-1048
Publisher:	John Wiley & Sons
Date Published:	2007-11-01
Start Page:	425
End Page:	428
Language:	English
DOI:	10.1111/j.1365-2141.2007.06658.x
PUBMED:	17910632
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-34848829782&partnerID=40&md5=30429298e9892ed562a5358ebba88444
Notes:	--- - "Cited By (since 1996): 28" - "Export Date: 17 November 2011" - "CODEN: BJHEA" - "Source: Scopus"

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