Chronic myelogenous leukemia Journal Article
| Authors: | O'Brien, S.; Berman, E.; Bhalla, K.; Copelan, E. A.; Devetten, M. P.; Emanuel, P. D.; Erba, H. P.; Greenberg, P. L.; Moore, J. O.; Przepiorka, D.; Radich, J. P.; Schilder, R. J.; Shami, P.; Smith, B. D.; Snyder, D. S.; Soiffer, R. J.; Tallman, M. S.; Talpaz, M.; Wetzler, M. |
| Article Title: | Chronic myelogenous leukemia |
| Abstract: | Chronic myelogenous leukemia (CML) accounts for 15% of adult leukemias. In 2007, an estimated 4500 cases will be diagnosed and 900 patients will die of the disease. The goal of CML therapy is complete remission, which typically progresses from hematologic to cytogenetic remission. These updated 2007 guidelines include changes to several treatment recommendations, including considerations for imatinib dosing, the use of interferon, and management of dasatinib toxicity. Recommendations for hematopoetic stem cell transplantation have also been updated. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | hydroxyurea; prednisone; clinical trial; fatigue; neutropenia; review; interferon; diarrhea; dose response; drug dose comparison; drug dose reduction; drug potentiation; drug withdrawal; side effect; neoadjuvant therapy; drug megadose; polymerase chain reaction; imatinib; drug inhibition; unindexed drug; edema; liver toxicity; lung toxicity; erythropoietin; anemia; gastrointestinal symptom; thrombocytopenia; genetic association; chromosomes, human, pair 9; cytogenetics; nccn clinical practice guidelines; calcium; dexamethasone; steroid; practice guideline; hematopoietic stem cell transplantation; dasatinib; chronic myeloid leukemia; transplantation; drug dose escalation; rash; liver failure; depression; cancer regression; drug antagonism; drug mechanism; phenobarbital; bone marrow biopsy; disease progression; paracetamol; cardiotoxicity; warfarin; graft versus host reaction; pleura effusion; autoimmune hemolytic anemia; headache; clarithromycin; drug blood level; liver function test; ketoconazole; chromosome aberrations; drug dose titration; mental concentration; memory; drug dose increase; drug substitution; chronic lymphatic leukemia; guidelines; pericardial effusion; growth factor; rifampicin; karyotyping; leukocytosis; simvastatin; graft versus leukemia effect; cyclosporin; diuretic agent; phenytoin; thrombocytosis; fluid retention; chronic myelogenous leukemia; aprepitant; carbamazepine; erythromycin; itraconazole; pimozide; rifabutin; muscle cramp; blast cell crisis; suicidal behavior; apheresis; kidney dysfunction; respiratory distress; philadelphia chromosome; parkinsonism; hypericum perforatum extract; anagrelide; desatinib; gastrointestinal agent; leukemia, myeloid, chronic |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 5 |
| Issue: | 5 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2007-05-01 |
| Start Page: | 474 |
| End Page: | 496 |
| Language: | English |
| PUBMED: | 17509252 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "Source: Scopus" |
