Squamous-cell carcinoma of the rectum: A rare but curable tumor Journal Article

Authors: Nahas, C. S. R.; Shia, J.; Joseph, R.; Schrag, D.; Minsky, B. D.; Weiser, M. R.; Guillem, J. G.; Paty, P. B.; Klimstra, D. S.; Tang, L. H.; Wong, W. D.; Temple, L. K.
Article Title: Squamous-cell carcinoma of the rectum: A rare but curable tumor
Abstract: PURPOSE: This study was designed to evaluate one institution's experience with treatment outcomes for rectal squamous-cell carcinoma. METHODS: Using our prospective Colorectal Database, we identified patients diagnosed with rectal squamous-cell carcinoma at our institution between 1983 and 2005. Pathology was rereviewed, tumor immunophenotype was compared to control cases of anal squamous-cell carcinoma and rectal adenocarcinoma, treatment modalities and outcomes were analyzed. RESULTS: Twelve patients were identified (10 females median age, 58 years). Median distal extent of tumors was 7 (range, 5-8) cm from the anal verge. Treatment included chemotherapy only (n=1), chemoradiation only (n=2), induction chemotherapy followed by chemoradiation and surgery (n=2), chemoradiation followed by surgery (n=5), and surgery followed by chemoradiation (n=2). The chemotherapy regimen was 5-fluorouracil-based. Radiotherapy total dose was 50.4 Gy (1.8 Gy/day, daily × 5) external iliac and inguinal nodes were not included in the radiation field. Complete clinical responders to chemoradiation (n=2) received no further treatment. All seven partial responders underwent surgery; six had complete pathologic response; nodal status in two of six was unknown because they had local excision. Immunophenotypical analysis showed similar keratin expression profile between rectal squamous-cell carcinoma (n=5) and rectal adenocarcinoma (n=5), which is different from anal squamous-cell carcinoma (n=10). All patients were alive without evidence of disease at follow-up (median follow-up, 2.6 (range, 0.5-16) years). CONCLUSIONS: Our data suggest that most patients treated with upfront chemoradiation therapy followed by surgery did well. Sphincter-preserving surgery is usually feasible. Clinical judgment of tumor response after chemoradiation is not completely reliable. Immunohistochemistry suggests a common cellular origin for rectal squamous-cell carcinoma and rectal adenocarcinoma, which is different from anal squamous-cell carcinoma. © 2007 The American Society of Colon and Rectal Surgeons.
Keywords: immunohistochemistry; adult; cancer chemotherapy; clinical article; controlled study; human tissue; protein expression; treatment outcome; aged; aged, 80 and over; middle aged; cancer surgery; survival rate; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; fluorouracil; united states; cancer patient; cancer radiotherapy; comparative study; radiotherapy, adjuvant; chemotherapy; follow up; methodology; follow-up studies; neoplasm staging; prospective study; prospective studies; multiple cycle treatment; antimetabolites, antineoplastic; radiotherapy; tumor markers, biological; continuous infusion; pathology; data base; feasibility study; experience; clinical evaluation; immunophenotyping; keratins; mitomycin; rectum carcinoma; rectal neoplasms; colectomy; anus sphincter; squamous-cell carcinoma; keratin; human papillomavirus; institutional care; anus carcinoma; rectal neoplasm; anus
Journal Title: Diseases of the Colon and Rectum
Volume: 50
Issue: 9
ISSN: 0012-3706
Publisher: Lippincott Williams & Wilkins  
Date Published: 2007-09-01
Start Page: 1393
End Page: 1400
Language: English
DOI: 10.1007/s10350-007-0256-z
PUBMED: 17661147
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 17 November 2011" - "CODEN: DICRA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Caio Sergio Rizkallah Nahas
    4 Nahas
  2. Romane Joseph
    2 Joseph
  3. Philip B Paty
    412 Paty
  4. Bruce Minsky
    306 Minsky
  5. Jose Guillem
    404 Guillem
  6. Deborah Schrag
    138 Schrag
  7. David S Klimstra
    948 Klimstra
  8. Jinru Shia
    583 Shia
  9. Martin R Weiser
    409 Weiser
  10. Laura Hong Tang
    382 Tang
  11. Larissa Temple
    190 Temple
  12. Douglas W Wong
    177 Wong