Resection of recurrent cervical cancer after total pelvic exenteration Journal Article

Authors: Mourton, S. M.; Sonoda, Y.; Abu-Rustum, N. R.; Bochner, B. H.; Barakat, R. R.; Chi, D. S.
Article Title: Resection of recurrent cervical cancer after total pelvic exenteration
Abstract: The objective of this study was to describe the management of patients with recurrent cervical cancer after total pelvic exenteration (TPE). We reviewed the records of patients who underwent TPE for recurrent cervical cancer between June 1992 and December 2003 and subsequently developed recurrent disease. Thirty-seven patients underwent TPE during the study period, and 25 (68%) subsequently developed recurrence proven by radiographic and/or biopsy studies. Recurrence sites included pelvic (12), inguinal (5), retroperitoneal (5), hepatic (4), vulva (2), perineum (1), transposed ovary (1), and lung (1). The median time to recurrence was 7 months (range 2-73 months), with 92% (23/25) occurring within 2 years of TPE. Management of recurrence was known in 21 of 25 patients, which included chemotherapy (10), surgical resection (7), and no further treatment (4). Surgically resected recurrences were isolated to the groin (2), vulva (2), perineum (1), transposed ovary (1), and psoas muscle (1). The four patients who underwent ovarian, perineal, and vulvar resections succumbed to their disease in a median time of 13 months (range 2-21 months). Of the two patients with surgically resected groin recurrences, one is alive with disease 21 months after initial recurrence and the other is alive without evidence of disease 85 months later. One patient had an isolated 4-cm recurrence involving the psoas muscle and the femoral nerve and is without the evidence of disease 9 months later. Resection of isolated recurrences after TPE is a reasonable option in selected patients, particularly in those with solitary inguinal metastases. © 2007, IGCS and ESGO.
Keywords: adult; cancer chemotherapy; cancer survival; clinical article; controlled study; human tissue; treatment outcome; aged; middle aged; cancer surgery; postoperative period; multimodality cancer therapy; cancer radiotherapy; disease free survival; recurrent cancer; pelvis; prospective studies; metastasis; neoplasm recurrence, local; tumor biopsy; medical record review; pathological anatomy; ovary; survival time; liver; uterine cervix cancer; pelvis exenteration; lung; platinum derivative; surgical resection; uterine cervical neoplasms; radiodiagnosis; retroperitoneum; cervical cancer; perineum; femoral nerve; pelvic exenteration; inguinal region; vulva; psoas muscle
Journal Title: International Journal of Gynecological Cancer
Volume: 17
Issue: 1
ISSN: 1048-891X
Publisher: Lippincott Williams & Wilkins  
Date Published: 2007-01-01
Start Page: 137
End Page: 140
Language: English
DOI: 10.1111/j.1525-1438.2007.00807.x
PUBMED: 17291244
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: IJGCE" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Richard R Barakat
    629 Barakat
  2. Dennis S Chi
    596 Chi
  3. Yukio Sonoda
    370 Sonoda
  4. Bernard Bochner
    399 Bochner