Dental status and risk of odontogenic complication in patients undergoing hematopoietic stem cell transplant Journal Article


Authors: Hansen, H. J.; Estilo, C.; Owosho, A.; Solano, A. K.; Randazzo, J.; Huryn, J.; Yom, S. H. K.
Article Title: Dental status and risk of odontogenic complication in patients undergoing hematopoietic stem cell transplant
Abstract: Purpose: Dental evaluation and management prior to hematopoietic stem cell transplant (HSCT) plays a vital role in identifying and treating infections that may be life-threatening. The purpose of this study is to describe the dental management of patients undergoing pre-HSCT examination with the Dental Service at Memorial Sloan Kettering Cancer Center (MSKCC) and to report on odontogenic complications. Methods: Patients referred for evaluation as part of the standard preparation for HSCT were included. Following clinical and radiological examination, patients were assigned to one of three groups based on risk of odontogenic infection, and treatment was provided as indicated. Patients were followed, and their medical records were reviewed for odontogenic complications during the transplant admission. Results: Of the 375 patients evaluated, 350 patients underwent HSCT: allogeneic 143 (40.9%) and autologous 207 (59.1%). The distribution of primary cancer diagnosis was as follows: multiple myeloma 104 (29.7%), leukemias 95 (27.1%), Hodgkin’s lymphoma 28 (8.0%), non-Hodgkin’s Lymphoma 99 (28.3%), and other conditions 24 (6.9%). The median time from dental evaluation to transplant was 29 days. The median Decayed, Missing, Filled Teeth Index was 17. The median Community Periodontal Index was 1. Based on dental status, 145 patients (41.4%) were classified as low risk, 133 (38%) as moderate risk and 72 (20.6%) as high risk of odontogenic infection. One hundred fourteen patients (32.6%) required dental treatment prior to HSCT, and 100 of these (28.6%) completed treatment. Two (0.57%) patients had odontogenic complications. Conclusions: With conservative pre-HSCT dental treatment based on an infection risk classification system, a low odontogenic complication rate was observed. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords: immunosuppression; supportive care; hematopoietic stem cell transplant; oral complications; dental evaluation and management; oral infection
Journal Title: Supportive Care in Cancer
Volume: 29
Issue: 4
ISSN: 0941-4355
Publisher: Springer Verlag  
Date Published: 2021-04-01
Start Page: 2231
End Page: 2238
Language: English
DOI: 10.1007/s00520-020-05733-1
PUBMED: 32901321
PROVIDER: scopus
PMCID: PMC8432266
DOI/URL:
Notes: Article -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Joseph M Huryn
    109 Huryn
  2. Cherry Estilo
    96 Estilo
  3. SaeHee Kim Yom
    43 Yom
  4. Armand Karl Solano
    4 Solano