Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy Journal Article


Authors: Zakeri, K.; Wang, H.; Kang, J. J.; Lee, A.; Romesser, P.; Mohamed, N.; Gelblum, D.; Sherman, E.; Dunn, L.; Boyle, J.; Wong, R.; Chen, L.; Yu, Y.; Tsai, C. J.; McBride, S. M.; Riaz, N.; Lee, N.
Article Title: Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy
Abstract: Background: Proton beam radiation therapy (PBRT) has dosimetric advantages compared to photon radiation therapy for the treatment of major salivary gland tumors (MSGTs). Methods: Patients with non-metastatic MSGTs treated at a single proton therapy center from October 2013 to October 2018 were retrospectively reviewed. Results: Sixty-eight patients with MSGTs were included and the most common site and histology were the parotid gland (75.0%) and adenoid cystic carcinoma (22.1%), respectively. The 3-year rates of locoregional control, progression-free survival, and overall survival were 95.1% (95% CI: 89.9%-100.0%), 80.7% (70.2%-92.7%), and 96.1% (95% CI: 90.9%-100.0%), respectively. Conclusion: In a large cohort of MSGTs treated with PBRT, the rates of locoregional control were high in short-term follow-up and treatment was well tolerated. © 2021 Wiley Periodicals LLC
Keywords: survival; adult; controlled study; aged; antibiotic agent; major clinical study; overall survival; cisplatin; treatment planning; cancer radiotherapy; outcome assessment; follow up; carboplatin; progression free survival; radiation; mucosa inflammation; nausea; retrospective study; dysphagia; karnofsky performance status; cancer fatigue; salivary gland; salivary gland tumor; dermatitis; chlorhexidine; cancer control; adenoid cystic carcinoma; acinar cell carcinoma; tumor classification; bone necrosis; radiation necrosis; perineural invasion; periodontal disease; liposarcoma; dysgeusia; desquamation; surgical margin; clinical target volume; skin pruritus; myoepithelial carcinoma; pleomorphic adenoma; salivary duct carcinoma; carcinoma ex pleomorphic adenoma; proton therapy; cancer prognosis; mucoepidermoid tumor; cancer; human; male; female; priority journal; article
Journal Title: Head & Neck
Volume: 43
Issue: 4
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 2021-04-01
Start Page: 1056
End Page: 1062
Language: English
DOI: 10.1002/hed.26563
PUBMED: 33606323
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Daphna Y Gelblum
    126 Gelblum
  2. Jay O Boyle
    118 Boyle
  3. Eric J Sherman
    234 Sherman
  4. Nadeem Riaz
    308 Riaz
  5. Nancy Y. Lee
    684 Lee
  6. Richard J Wong
    284 Wong
  7. Sean Matthew McBride
    197 McBride
  8. Lara   Dunn
    80 Dunn
  9. Chiaojung Jillian   Tsai
    180 Tsai
  10. Anna Lee
    43 Lee
  11. Yao Yu
    39 Yu
  12. Jung Yun Kang
    30 Kang
  13. Linda Chang Chen
    26 Chen
  14. Kaveh Zakeri
    21 Zakeri
  15. Huili Wang
    10 Wang