Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy Journal Article
| Authors: | Zakeri, K.; Wang, H.; Kang, J. J.; Lee, A.; Romesser, P.; Mohamed, N.; Gelblum, D.; Sherman, E.; Dunn, L.; Boyle, J.; Wong, R.; Chen, L.; Yu, Y.; Tsai, C. J.; McBride, S. M.; Riaz, N.; Lee, N. |
| Article Title: | Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy |
| Abstract: | Background: Proton beam radiation therapy (PBRT) has dosimetric advantages compared to photon radiation therapy for the treatment of major salivary gland tumors (MSGTs). Methods: Patients with non-metastatic MSGTs treated at a single proton therapy center from October 2013 to October 2018 were retrospectively reviewed. Results: Sixty-eight patients with MSGTs were included and the most common site and histology were the parotid gland (75.0%) and adenoid cystic carcinoma (22.1%), respectively. The 3-year rates of locoregional control, progression-free survival, and overall survival were 95.1% (95% CI: 89.9%-100.0%), 80.7% (70.2%-92.7%), and 96.1% (95% CI: 90.9%-100.0%), respectively. Conclusion: In a large cohort of MSGTs treated with PBRT, the rates of locoregional control were high in short-term follow-up and treatment was well tolerated. © 2021 Wiley Periodicals LLC |
| Keywords: | survival; adult; controlled study; aged; antibiotic agent; major clinical study; overall survival; cisplatin; treatment planning; cancer radiotherapy; outcome assessment; follow up; carboplatin; progression free survival; radiation; mucosa inflammation; nausea; retrospective study; dysphagia; karnofsky performance status; cancer fatigue; salivary gland; salivary gland tumor; dermatitis; chlorhexidine; cancer control; adenoid cystic carcinoma; acinar cell carcinoma; tumor classification; bone necrosis; radiation necrosis; perineural invasion; periodontal disease; liposarcoma; dysgeusia; desquamation; surgical margin; clinical target volume; skin pruritus; myoepithelial carcinoma; pleomorphic adenoma; salivary duct carcinoma; carcinoma ex pleomorphic adenoma; proton therapy; cancer prognosis; mucoepidermoid tumor; cancer; human; male; female; priority journal; article |
| Journal Title: | Head & Neck |
| Volume: | 43 |
| Issue: | 4 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2021-04-01 |
| Start Page: | 1056 |
| End Page: | 1062 |
| Language: | English |
| DOI: | 10.1002/hed.26563 |
| PUBMED: | 33606323 |
| PROVIDER: | scopus |
| PMCID: | PMC9371938 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2021 -- Source: Scopus |
