Comparative analysis of the Memorial Sloan Kettering Bowel Function Instrument and the Low Anterior Resection Syndrome Questionnaire for assessment of bowel dysfunction in rectal cancer patients after low anterior resection Journal Article

   

Authors:	Quezada-Diaz, F. F.; Elfeki, H.; Emmertsen, K. J.; Pappou, E. P.; Jimenez-Rodriguez, R.; Patil, S.; Laurberg, S.; Garcia-Aguilar, J.
Article Title:	Comparative analysis of the Memorial Sloan Kettering Bowel Function Instrument and the Low Anterior Resection Syndrome Questionnaire for assessment of bowel dysfunction in rectal cancer patients after low anterior resection
Abstract:	Aim: Neoadjuvant therapy and total mesorectal excision (TME) for rectal cancer are associated with bowel dysfunction symptoms known as low anterior resection syndrome (LARS). Our study compared the only two validated instruments—the LARS Questionnaire (LARS-Q) and the Memorial Sloan Kettering Bowel Function Instrument (MSK-BFI)—in rectal cancer patients undergoing sphincter-preserving TME. Methods: One hundred and ninety patients undergoing sphincter-preserving TME for Stage I–III rectal cancer completed the MSK-BFI and LARS-Q simultaneously at a median time of 12 (range 1–43) months after restoration of bowel continuity. Associations between the MSK-BFI total/subscale scores and the LARS-Q score were investigated using Spearman rank correlation (r s). Discriminant validity for the two questionnaires was assessed, and the questionnaires were compared with the European Quality of Life Instrument. Results: Major LARS was identified in 62% of patients. The median MSK-BFI scores for no LARS, minor LARS and major LARS were 76.5, 70 and 57, respectively. We found a strong association between MSK-BFI and LARS-Q (r s −0.79). The urgency/soilage subscale (r s −0.7) and the frequency subscale (rs −0.68) of MSK-BFI strongly correlated with LARS-Q. Low correlation was observed between the MSK-BFI diet subscale and LARS-Q (r s −0.39). On multivariate analysis, both questionnaires showed worse bowel function in patients with distal tumours. A low to moderate correlation with the European Quality of Life Instrument was observed for both questionnaires. Conclusions: The MSK-BFI and LARS-Q showed good correlation and similar discriminant validity. As the LARS-Q is easier to complete, it may be considered the preferred tool to screen for bowel dysfunction. © 2021 The Association of Coloproctology of Great Britain and Ireland
Keywords:	adult; controlled study; aged; major clinical study; postoperative period; cancer patient; comparative study; cancer staging; quality of life; cohort analysis; retrospective study; questionnaire; correlation analysis; ileostomy; scoring system; intermethod comparison; discriminant validity; multivariate analysis; sex difference; intestine function; rectum cancer; enteropathy; rectal cancer; rectum anterior resection; total mesorectal excision; proctectomy; bowel function; colorectal anastomosis; human; male; female; priority journal; article; european quality of life 5 dimensions questionnaire; lars score; low anterior resection syndrome; mskcc-bfi score; low anterior resection syndrome questionnaire; memorial sloan kettering bowel function instrument
Journal Title:	Colorectal Disease
Volume:	23
Issue:	2
ISSN:	1462-8910
Publisher:	Wiley Blackwell
Date Published:	2021-02-01
Start Page:	451
End Page:	460
Language:	English
DOI:	10.1111/codi.15515
PUBMED:	33405307
PROVIDER:	scopus
PMCID:	PMC8023229
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100763266&doi=10.1111%2fcodi.15515&partnerID=40&md5=adcab4c57235be41c7405ddcd6bb6b76
Notes:	Article -- Export Date: 1 April 2021 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/178464