Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients Miscellaneous

Authors: Liao, C.; Taylor, B. P.; Ceccarani, C.; Fontana, E.; Amoretti, L. A.; Wright, R. J.; Gomes, A. L. C.; Peled, J. U.; Taur, Y.; Perales, M. A.; van den Brink, M. R. M.; Littmann, E.; Pamer, E. G.; Schluter, J.; Xavier, J. B.
Title: Compilation of longitudinal microbiota data and hospitalome from hematopoietic cell transplantation patients
Abstract: The impact of the gut microbiota in human health is affected by several factors including its composition, drug administrations, therapeutic interventions and underlying diseases. Unfortunately, many human microbiota datasets available publicly were collected to study the impact of single variables, and typically consist of outpatients in cross-sectional studies, have small sample numbers and/or lack metadata to account for confounders. These limitations can complicate reusing the data for questions outside their original focus. Here, we provide comprehensive longitudinal patient dataset that overcomes those limitations: a collection of fecal microbiota compositions (>10,000 microbiota samples from >1,000 patients) and a rich description of the “hospitalome” experienced by the hosts, i.e., their drug exposures and other metadata from patients with cancer, hospitalized to receive allogeneic hematopoietic cell transplantation (allo-HCT) at a large cancer center in the United States. We present five examples of how to apply these data to address clinical and scientific questions on host-associated microbial communities. © 2021, The Author(s).
Keywords: genetics; united states; hematopoietic stem cell transplantation; hospitalization; intestine flora; microbiology; rna 16s; feces; rna, ribosomal, 16s; humans; human; gastrointestinal microbiome
Journal Title: Scientific Data
Volume: 8
ISSN: 2052-4463
Publisher: Nature Publishing Group  
Date Published: 2021-03-02
Start Page: 71
Language: English
DOI: 10.1038/s41597-021-00860-8
PUBMED: 33654104
PROVIDER: scopus
PMCID: PMC7925583
Notes: Data Paper -- Correction issued, see DOI 10.1038/s41597-021-00903-0 -- Export Date: 1 April 2021 -- Source: Scopus
Citation Impact
MSK Authors
  1. Miguel-Angel Perales
    631 Perales
  2. Joao Debivar Xavier
    86 Xavier
  3. Ying Taur
    131 Taur
  4. Jonathan U Peled
    100 Peled
  5. Emily Fontana
    24 Fontana
  6. Antonio LC Gomes
    39 Gomes
  7. Bradford P Taylor
    8 Taylor
  8. Chen Liao
    9 Liao
  9. Roberta Justine Wright
    12 Wright