Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations Journal Article

   


Authors: Iyengar, N. M.; Zhou, X. K.; Mendieta, H.; El-Hely, O.; Giri, D. D.; Winston, L.; Falcone, D. J.; Wang, H.; Meng, L.; Ha, T.; Pollak, M.; Morrow, M.; Dannenberg, A. J.
Article Title: Effects of obesity on breast aromatase expression and systemic metabo-inflammation in women with BRCA1 or BRCA2 mutations
Abstract: Obesity is associated with an increased risk of breast cancer in post-menopausal women and decreased risk in pre-menopausal women. Conversely, in BRCA1/2 mutation carriers, pre-menopausal obesity is associated with early-onset breast cancer. Here we show that obese, pre-menopausal BRCA1/2 mutation carriers have increased levels of aromatase and inflammation in the breast, as occurs in post-menopausal women. In a prospective cohort study of 141 women with germline BRCA1 (n = 74) or BRCA2 (n = 67) mutations, leptin, and aromatase expression were higher in the breast tissue of obese versus lean individuals (P < 0.05). Obesity was associated with breast white adipose tissue inflammation, which correlated with breast aromatase levels (P < 0.01). Circulating C-reactive protein, interleukin-6, and leptin positively correlated with body mass index and breast aromatase levels, whereas negative correlations were observed for adiponectin and sex hormone-binding globulin (P < 0.05). These findings could help explain the increased risk of early-onset breast cancer in obese BRCA1/2 mutation carriers. © 2021, The Author(s).
Journal Title: npj Breast Cancer
Volume: 7
ISSN: 2374-4677
Publisher: Nature Publishing Group  
Date Published: 2021-03-01
Start Page: 18
Language: English
DOI: 10.1038/s41523-021-00226-8
PROVIDER: scopus
PMCID: PMC7921427
PUBMED: 33649363
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101816245&doi=10.1038%2fs41523-021-00226-8&partnerID=40&md5=d72d50d98910b71b4651314424bb3bee
Notes: Article -- Export Date: 1 April 2021 -- Source: Scopus
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MSK Authors
  1. Monica Morrow
    773 Morrow
  2. Dilip D Giri
    184 Giri
  3. Neil Mukund Iyengar
    154 Iyengar
  4. Hillary Mendieta
    3 Mendieta
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