Survival outcomes of screening with breast MRI in women at elevated risk of breast cancer Journal Article
| Authors: | Bae, M. S.; Sung, J. S.; Bernard-Davila, B.; Sutton, E. J.; Comstock, C. E.; Morris, E. A. |
| Article Title: | Survival outcomes of screening with breast MRI in women at elevated risk of breast cancer |
| Abstract: | Objective: To determine survival outcomes in women with breast cancer detected at combined screening with breast MRI and mammography versus screening mammography alone. Methods: This is an institutional review board-approved retrospective study, and the need for informed consent was waived. A total of 3002 women with an increased risk of breast cancer were screened between 2001 and 2004. Of the 3002 women, 1534 (51.1%) had 2780 combined screenings (MRI and mammography) and 1468 (48.9%) had 4811 mammography-only screenings. The Χ2 test and the Kaplan-Meier method were used to compare cancer detection rates and survival rates. Results: The overall cancer detection rate was significantly higher in the MRI plus mammography group compared with the mammography-only group (1.4% [40 of 2780] vs 0.5% [23 of 4811]; P < 0.001). No interval cancers occurred in the MRI plus mammography group, whereas 9 interval cancers were found in the mammography-only group. During a median follow-up of 10.9 years (range: 0.7 to 15.2), a total of 11 recurrences and 5 deaths occurred. Of the 11 recurrences, 6 were in the MRI plus mammography group and 5 were in the mammography-only group. All five deaths occurred in the mammography-only group. Disease-free survival showed no statistically significant difference between the two groups (P = 0.32). However, overall survival was significantly improved in the MRI plus mammography group (P = 0.002). Conclusion: Combined screening with MRI and mammography in women at elevated risk of breast cancer improves cancer detection and overall survival. © Society of Breast Imaging 2020. All rights reserved. |
| Keywords: | mammography; screening; mri; survival breast cancer |
| Journal Title: | Journal of Breast Imaging |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 2631-6110 |
| Publisher: | Oxford University Press |
| Date Published: | 2020-01-01 |
| Start Page: | 29 |
| End Page: | 35 |
| Language: | English |
| DOI: | 10.1093/jbi/wbz083 |
| PROVIDER: | scopus |
| PMCID: | PMC6999769 |
| PUBMED: | 32055796 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2021 -- Source: Scopus |
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