Monoclonal antibody therapy of APL Journal Article

  


Authors: Maslak, P. G.; Jurcic, J. G.; Scheinberg, D. A.
Article Title: Monoclonal antibody therapy of APL
Abstract: Acute promyelocytic leukemia (APL) is a rare subtype of acute myeloid leukemia (AML) for which a number of targeted therapies have been developed. The "targets" have included both genotypic and phenotypic features of the disease. The application of monoclonal antibodies (MAbs) to this disease to date have been limited to a relatively small number of studies where this therapy has been used to supplement effective approaches to the disease. The preliminary results have been promising, and further development of this modality as an effective adjunct to existing treatment regimens will most certainly occur in the near future. © Springer-Verlag 2007.
Keywords: treatment outcome; unclassified drug; acute granulocytic leukemia; clinical trial; review; monotherapy; nonhuman; side effect; antineoplastic agents; drug targeting; cytarabine; methotrexate; rituximab; outcome assessment; antineoplastic agent; mouse; phenotype; animal; animals; mice; imatinib; etoposide; genotype; cytogenetics; dexamethasone; cell differentiation; cancer research; cancer therapy; monoclonal antibody; aminotransferase blood level; arsenic trioxide; leukemia, promyelocytic, acute; patient care; immunology; antibodies, monoclonal; mitoxantrone; daunorubicin; promyelocytic leukemia; immunophenotyping; hyperbilirubinemia; idarubicin; antigens, cd; anthracycline; bone marrow transplantation; retinoic acid; leukocyte antigen; alemtuzumab; liver injury; cd33 antigen; gemtuzumab ozogamicin; mercaptopurine; differentiation antigen; antigens, differentiation, myelomonocytic; human monoclonal antibody; aminoglycoside; aminoglycosides; sinusoidal obstruction syndrome; liver vein obstruction; hl-60 cells; cell strain hl 60; m 195 monoclonal antibody; gemtuzumab
Journal Title: Current Topics in Microbiology and Immunology
Volume: 313
ISSN: 0070-217X
Publisher: Springer Verlag  
Date Published: 2007-01-01
Start Page: 205
End Page: 219
Language: English
PUBMED: 17217045
PROVIDER: scopus
DOI: 10.1007/978-3-540-34594-7_11
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33846983300&partnerID=40&md5=dcbd96e43c631d92bcf648b8c1280f68
Notes: --- Chapter in "Acute Promyelocytic Leukemia: Molecular Genetics, Mouse Models and Targeted Therapy" (ISBN: 978-3-540-34592-3) - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: CTMIA" - "Source: Scopus"
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MSK Authors
  1. Joseph G Jurcic
    134 Jurcic
  2. David Scheinberg
    499 Scheinberg
  3. Peter Maslak
    197 Maslak
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