Reduced-order parameter optimization for simplifying prostate IMRT planning Journal Article
| Authors: | Lu, R.; Radke, R. J.; Happersett, L.; Yang, J.; Chui, C. S.; Yorke, E.; Jackson, A. |
| Article Title: | Reduced-order parameter optimization for simplifying prostate IMRT planning |
| Abstract: | Intensity-modulated radiotherapy (IMRT) has become an effective tool for cancer treatment with radiation. However, even expert radiation planners still need to spend a substantial amount of time manually adjusting IMRT optimization parameters such as dose limits and costlet weights in order to obtain a clinically acceptable plan. In this paper, we describe two main advances that simplify the parameter adjustment process for five-field prostate IMRT planning. First, we report the results of a sensitivity analysis that quantifies the effect of each hand-tunable parameter of the IMRT cost function on each clinical objective and the overall quality of the resulting plan. Second, we show that a recursive random search over the six most sensitive parameters as an outer loop in IMRT planning can quickly and automatically determine parameters for the cost function that lead to a plan meeting the clinical requirements. Our experiments on a ten-patient dataset show that for 70% of the cases, we can automatically determine a plan in 10 min (on the average) that is either clinically acceptable or requires only minor adjustment by the planner. The outer-loop optimization can be easily integrated into a traditional IMRT planning system. © 2007 IOP Publishing Ltd. |
| Keywords: | clinical article; intensity modulated radiation therapy; treatment planning; radiation dose; sensitivity and specificity; sensitivity analysis; statistics; radiotherapy; algorithms; automation; prostate cancer; prostatic neoplasms; health care quality; prostate; algorithm; radiotherapy, intensity-modulated; dosimetry; models, statistical; prostate tumor; radiotherapy planning, computer-assisted; computer assisted radiotherapy; statistical model; optimization; parameter estimation; biophysics; radiological parameters; intensity-modulated radiotherapy (imrt); medical problems; light modulation; prosthetics; outer-loop optimization; parameter optimization; tunable parameters |
| Journal Title: | Physics in Medicine and Biology |
| Volume: | 52 |
| Issue: | 3 |
| ISSN: | 0031-9155 |
| Publisher: | IOP Publishing Ltd |
| Date Published: | 2007-02-07 |
| Start Page: | 849 |
| End Page: | 870 |
| Language: | English |
| DOI: | 10.1088/0031-9155/52/3/022 |
| PUBMED: | 17228125 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "Art. No.: 022" - "CODEN: PHMBA" - "Source: Scopus" |
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253Jackson -
450Yorke -
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144
Chui
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