Myoepithelial carcinoma Review

   


Authors: Xu, B.; Katabi, N.
Review Title: Myoepithelial carcinoma
Abstract: Myoepithelial carcinoma (MECA) may overlap histologically with other salivary gland neoplasms, especially pleomorphic adenoma. MECA is characterized by cellular, uniform growth of myoepithelial cells and multinodular expansile invasive pattern with zonal cellular distribution. It may arise de novo or in association with pleomorphic adenoma (myoepithelial carcinoma ex pleomorphic adenoma). By immunohistochemistry, MECA is positive for cytokeratins and at least one of the myoepithelial markers, including S100. PLAG1 fusion is the most common genetic alteration. Carcinoma ex pleomorphic adenoma and necrosis correlate with worse clinical outcome in MECA, and necrosis can be used to stratify MECA as high grade. © 2020 Elsevier Inc.
Keywords: myoepithelial carcinoma; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; plag1
Journal Title: Surgical Pathology Clinics
Volume: 14
Issue: 1
ISSN: 1875-9181
Publisher: Elsevier Inc.  
Date Published: 2021-03-01
Start Page: 67
End Page: 73
Language: English
DOI: 10.1016/j.path.2020.09.008
PUBMED: 33526224
PROVIDER: scopus
PMCID: PMC8522910
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098885499&doi=10.1016%2fj.path.2020.09.008&partnerID=40&md5=a0e28625d19cb5aedd47b15a06b511d8
Notes: Review -- Export Date: 1 March 2021 -- Source: Scopus
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MSK Authors
  1. Nora Katabi
    306 Katabi
  2. Bin Xu
    229 Xu
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