Oral self-management of palbociclib (Ibrance®) using mobile technology protocol Journal Article


Authors: Mazzella Ebstein, A. M.; Barton-Burke, M.; Anthony, V.; Smith, A.; Zhang, Z.; Robson, M.
Article Title: Oral self-management of palbociclib (Ibrance®) using mobile technology protocol
Abstract: Aim: This study will test the feasibility and effectiveness of mobile technology intervention on the patients’ self-management of oral anticancer medication. Secondary objectives include acceptability, the usefulness of text messages, and satisfaction by participants and nurses. Methods: This prospective two-arm study will recruit patients (N = 220) with metastatic breast cancer and initiating treatment with palbociclib (Ibrance ®). Allowing for attrition, patients will be randomized into the control (N = 100) or intervention (N = 100) group. Unidirectional text message reminders will be sent during the treatment cycle through a secure web application using the patient's smartphone. Self-reported survey responses will be collected at three time points; at consent, end of treatment cycles, and the follow-up clinic visit and include a demographic questionnaire, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Post study questionnaire and the R-15 Patient Satisfaction Questionnaire. Nurses providing care for study patients will complete the Adaptation of Stamps Nurse Workload questionnaire. Data will be analysed an intent-to-treat analysis comparing the two arms. Study approval was obtained in December 2019 and funded in January 2020. Discussion: Smartphones are globally available and have text messaging capability which is increasingly being used as an intervention in healthcare studies. This study will test a low-cost, nurse-led intervention that enhances the patient's experience with oral anti-cancer medications, improves access to care, reduces costs, and improves the satisfaction of nurses caring for oncology patients. Impact: Despite the ease of administering oral anti-cancer medications, oncology patients maynot take them as prescribed and consequently, these factors affect patient outcomes and disease control. Given the importance of taking oral anti-cancer medications and the difficulties patients experience in achieving it, the effective use of mobile technology interventions can actively engage patients in their care and improve medication self-management of anticancer treatment regimens. © 2020 John Wiley & Sons Ltd
Keywords: nursing; nurses; text messaging; cancer; mobile technology; medication self-management; midwives
Journal Title: Journal of Advanced Nursing
Volume: 77
Issue: 3
ISSN: 0309-2402
Publisher: John Wiley & Sons  
Date Published: 2021-03-01
Start Page: 1556
End Page: 1566
Language: English
DOI: 10.1111/jan.14659
PROVIDER: scopus
PUBMED: 33245144
PMCID: PMC8454747
DOI/URL:
Notes: Article -- Export Date: 1 March 2021 -- Source: Scopus
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  1. Zhigang Zhang
    430 Zhang
  2. Mark E Robson
    681 Robson
  3. Andrea Cameron Marie Smith
    13 Smith