Empirical and rational design of T cell receptor-based immunotherapies Review
| Authors: | Jones, H. F.; Molvi, Z.; Klatt, M. G.; Dao, T.; Scheinberg, D. A. |
| Review Title: | Empirical and rational design of T cell receptor-based immunotherapies |
| Abstract: | The use of T cells reactive with intracellular tumor-associated or tumor-specific antigens has been a promising strategy for cancer immunotherapies in the past three decades, but the approach has been constrained by a limited understanding of the T cell receptor’s (TCR) complex functions and specificities. Newer TCR and T cell-based approaches are in development, including engineered adoptive T cells with enhanced TCR affinities, TCR mimic antibodies, and T cell-redirecting bispecific agents. These new therapeutic modalities are exciting opportunities by which TCR recognition can be further exploited for therapeutic benefit. In this review we summarize the development of TCR-based therapeutic strategies and focus on balancing efficacy and potency versus specificity, and hence, possible toxicity, of these powerful therapeutic modalities. © Copyright © 2021 Jones, Molvi, Klatt, Dao and Scheinberg. |
| Keywords: | t cell receptor; tumor infiltrating lymphocytes; cross-reactivity; bispecific t cell engager; immune mobilizing monoclonal t cell receptors against cancer; peptide- major histocompatibility complexes; t cell receptor mimic monoclonal antibody; t cell receptor-t cell |
| Journal Title: | Frontiers in Immunology |
| Volume: | 11 |
| ISSN: | 1664-3224 |
| Publisher: | Frontiers Media S.A. |
| Date Published: | 2021-01-25 |
| Start Page: | 585385 |
| Language: | English |
| DOI: | 10.3389/fimmu.2020.585385 |
| PROVIDER: | scopus |
| PMCID: | PMC7868419 |
| PUBMED: | 33569049 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 March 2021 -- Source: Scopus |
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