The aged microenvironment of melanoma feeds escape from targeted therapy Editorial

  


Authors: Montal, E. D.; White, R. M.
Title: The aged microenvironment of melanoma feeds escape from targeted therapy
Abstract: Alicea and colleagues demonstrate that aged fibroblasts secrete lipids into the tumor microenviroment, allowing for nutrient exchange with melanoma cells. This supportive function of fibroblasts results in increased resistance to BRAF/MEKi therapy in the context of an aged microenvironment, providing crucial mechanistic insight into age-related drug resistance. © 2020 American Association for Cancer Research.
Journal Title: Cancer Discovery
Volume: 10
Issue: 9
ISSN: 2159-8274
Publisher: American Association for Cancer Research  
Date Published: 2020-09-01
Start Page: 1255
End Page: 1257
Language: English
DOI: 10.1158/2159-8290.Cd-20-0949
PROVIDER: scopus
PUBMED: 32873617
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100257641&doi=10.1158%2f2159-8290.CD-20-0949&partnerID=40&md5=8e485382f26c2e31c4674286741eb943
Notes: Article -- Export Date: 1 March 2021 -- Source: Scopus
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MSK Authors
  1. Richard Mark White
    68 White
  2. Emily Dina Montal
    14 Montal
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