Aromatization of androstenedione to estrogen by benign prostatic hyperplasia, prostate cancer and expressed prostatic secretions Journal Article
| Authors: | Stone, N. N.; Laudone, V. P.; Fair, W. R.; Fishman, J. |
| Article Title: | Aromatization of androstenedione to estrogen by benign prostatic hyperplasia, prostate cancer and expressed prostatic secretions |
| Abstract: | Human prostatic tissue and expressed prostatic secretions (EPS) efrom patients with benign prostatic hyperplasia (BPH) and prostate cancer were incubated with (1 β 3H) androstenedione. The extent of aromatization was determined by measuring the transfer of 3H from the 1 β position into water. The amount of 3H2O recovered corresponds to the estrogens formed. Tissue from 5 patients with BPH yielded 2.13 (±1.05) pmol/mg protein/h while the EPS from the same patients yielded 727 fmol/mg protein/h. In patients with prostate cancer the mean formation of estrogens was 388 fmol/mg protein/h (±75). 4-hydroxyandrostenedione, an aromatase inhibitor, successfully inhibited aromatization in BPH and prostate cancer 53-98%. © 1987 Springer-Verlag. |
| Keywords: | estrogens; dose-response relationship, drug; prostate cancer; prostatic neoplasms; prostate; hyperplasia; carrier proteins; androstenedione; aromatization; bph; human; male; priority journal; prostatic secretions |
| Journal Title: | Urological Research |
| Volume: | 15 |
| Issue: | 3 |
| ISSN: | 0300-5623 |
| Publisher: | Springer |
| Date Published: | 1987-06-01 |
| Start Page: | 165 |
| End Page: | 167 |
| Language: | English |
| DOI: | 10.1007/bf00254430 |
| PUBMED: | 3629751 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
