Quantification of the sulfates of 16α-hydroxy androgens that are possible precursors of estriol-3-sulfate in human breast cyst fluid Journal Article
| Authors: | Raju, U.; Levitz, M.; Jacobowitz, G.; Fleisher, M.; Bencsath, F. A.; Field, F. H.; Breed, C. N.; Naganuma, H.; Bradlow, H. L. |
| Article Title: | Quantification of the sulfates of 16α-hydroxy androgens that are possible precursors of estriol-3-sulfate in human breast cyst fluid |
| Abstract: | The concentration of 16α-hydroxydehydroepiandrosterone-3-sulfate (16α-OHDHAS) was determined in 29 samples of human breast cvst fluid (BCF)and in 15 of these, androst-5-ene-3β,16α,17β-triol-3-sulfate (A-TriolS) was also assayed. The median value of both was about 100 ng/mL and the ranges were from 1.4 to about 1800 ng/mL. There was a significant association in the values for the two sulfates (p<0.05). These concentrations are consistent with a role for 16α-hydroxy androgens as possible precursors for estriol-3-sulfate. The latter is highly elevated relative to other body fluids in BCF. The androgens also correlated directly with the concentrations of K+, an indicator of apocrine proliferation of breast cysts. © 1988. |
| Keywords: | clinical article; human cell; androgen; methodology; body fluids; radioisotope; mass fragmentography; sodium; potassium; sulfates; prasterone; human; female; support, u.s. gov't, p.h.s.; breast cyst; fibrocystic disease of breast; estriol; 16alpha hydroxyprasterone 3 sulfate; estriol 3 sulfate; androstenols |
| Journal Title: | Steroids |
| Volume: | 50 |
| Issue: | 4-6 |
| ISSN: | 0039-128X |
| Publisher: | Elsevier Inc. |
| Date Published: | 1987-10-01 |
| Start Page: | 559 |
| End Page: | 574 |
| Language: | English |
| DOI: | 10.1016/0039-128x(87)90039-0 |
| PUBMED: | 2974194 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
