Cocaine and morphine interaction in acute and chronic cancer pain Journal Article

  


Authors: Kaiko, R. F.; Kanner, R.; Foley, K. M.; Wallenstein, S. L.; Canel, A. M.; Rogers, A. G.; Houde, R. W.
Article Title: Cocaine and morphine interaction in acute and chronic cancer pain
Abstract: An evaluation of the analgesic, mood and side effects of the combination of intramuscular morphine and oral cocaine was conducted in 17 patients with postoperative pain and 19 others with chronic malignant pain for the purpose of assessing the therapeutic merits of so-called 'euphoriant' elixirs in the management of pain in cancer patients. The study was designed as a randomized and double-blind single dose but complete cross-over comparison of the combination of 10 mg intramuscular morphine and 10 mg oral cocaine with morphine alone, cocaine alone, and placebo. While patients clearly discriminated between the analgesic effects of morphine and placebo, there were no differences in the analgesic responses to cocaine and placebo, or in responses to morphine and the combination of morphine and cocaine in either patient group. Side effects were predominantly morphine-like and occurred in 59% of patients after the combination, 43% after morphine, 34% after cocaine and 25% after placebo. Interaction effects between cocaine and morphine were observed in terms of positive changes toward selected aspects of mood (e.g., cheerful, friendly) in postoperative patients but toward negative aspects of mood (e.g., sad, serious) in patients with chronic pain. © 1987.
Keywords: adult; clinical article; aged; middle aged; neoplasms; pain; cancer pain; drug synergism; drug therapy, combination; diagnosis; chronic pain; morphine; analgesics; double-blind method; postoperative pain; pain, postoperative; adverse drug reaction; therapy; clinical trials; analgesic agent; oral drug administration; random allocation; nervous system; drug interaction; intramuscular drug administration; etiology; cocaine; humans; human; male; female
Journal Title: Pain
Volume: 31
Issue: 1
ISSN: 0304-3959
Publisher: Elsevier Science BV  
Date Published: 1987-10-01
Start Page: 35
End Page: 45
Language: English
DOI: 10.1016/0304-3959(87)90004-2
PUBMED: 3320880
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023252248&doi=10.1016%2f0304-3959%2887%2990004-2&partnerID=40&md5=e8479f938ba37126e79a18f3e1d4e173
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus
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MSK Authors
  1. Kathleen M Foley
    199 Foley
  2. Raymond Houde
    26 Houde
  3. Ada Rogers
    30 Rogers
  4. Stanley L. Wallenstein
    15 Wallenstein
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