Depression, anxiety and quality of life in a chronic lymphocytic leukemia cohort Journal Article


Authors: Levin, T. T.; Li, Y.; Riskind, J.; Rai, K.
Article Title: Depression, anxiety and quality of life in a chronic lymphocytic leukemia cohort
Abstract: Objective: Although chronic lymphocytic leukemia (CLL) accounts for 25-30% of leukemia cases, little is known about its psychosocial correlates. This study examines anxiety, depression and quality of life (QOL) in a CLL cohort. Methods: One hundred five patients recruited from a CLL research database were classified into two groups: "watch and wait" or active treatment. The patients completed a mail-in battery of depression, anxiety and QOL measures. Results: There was no statistical difference between depression, anxiety and physical/mental QOL in "watch and wait" versus active-treatment groups. Patients ≤60 years reported more depression (P=.014) and worse emotional (P=.0001) and social QOL (P=.002). They also had more "watch and wait" anxiety (P=.052). Social and emotional QOL were similar in both newly diagnosed patients and those diagnosed >6 years ago, although physical QOL worsens with time (P=.05). Conclusion: Depression, anxiety and QOL are remarkably similar in "watch and wait" versus actively treated CLL, despite the latter group having, by definition, later stage disease. Patients ≤60 years are more depressed and have reduced emotional and social QOL. Younger "watch and wait" patients are more anxious. Patients diagnosed for more than 6 years have a worse physical QOL, but their social and emotional QOL are similar to those of newly diagnosed patients. © 2007 Elsevier Inc. All rights reserved.
Keywords: adult; controlled study; aged; middle aged; major clinical study; quality of life; cohort studies; health survey; cancer therapy; sickness impact profile; depression; anxiety disorder; anxiety; age distribution; new york; chronic lymphatic leukemia; databases, factual; emotionality; leukemia, lymphocytic, chronic, b-cell; physical capacity; social psychology; social behavior; chronic lymphocytic leukemia; mental capacity
Journal Title: General Hospital Psychiatry
Volume: 29
Issue: 3
ISSN: 0163-8343
Publisher: Elsevier Science, Inc.  
Date Published: 2007-05-01
Start Page: 251
End Page: 256
Language: English
DOI: 10.1016/j.genhosppsych.2007.01.014
PUBMED: 17484943
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: GHPSD" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Yuelin Li
    157 Li
  2. Tomer T Levin
    60 Levin