Carcinosarcoma of the ovary treated with platinum and taxane: The Memorial Sloan-Kettering Cancer Center experience Journal Article

Authors: Leiser, A. L.; Chi, D. S.; Ishill, N. M.; Tew, W. P.
Article Title: Carcinosarcoma of the ovary treated with platinum and taxane: The Memorial Sloan-Kettering Cancer Center experience
Abstract: Introduction.: Due to the rarity of ovarian carcinosarcomas, the optimal chemotherapeutic regimen to treat this aggressive disease is yet to be determined. The purpose of this study was to determine the response rate, recurrence-free survival, and overall survival of patients with ovarian carcinosarcoma who were treated with the combination of platinum and a taxane as first-line chemotherapy. Methods.: We identified all patients with ovarian carcinosarcoma who received a combination of platinum and taxane either after initial tumor resection or as neoadjuvant therapy. Data extracted from the medical records included residual tumor after surgery, number, type and dose of chemotherapy cycles, tumor response, and survival outcome. Results.: Between 1991 and 2005, 30 patients were identified for analysis. Twenty-four patients had stage III disease, 5 had stage IV disease, and 1 had stage II disease. All patients underwent surgical resection and 17 (57%) were cytoreduced to less than 1 cm. Twenty-eight patients received chemotherapy after surgery, and 2 patients received chemotherapy before surgery. Twenty-four patients (80%) received carboplatin and paclitaxel, 3 (10%) received carboplatin and docetaxel, and 3 (10%) received cisplatin and paclitaxel. Twelve (40%) had a complete response, 7 (23%) a partial response, 2 (7%) stable disease, and 9 (30%) progression of disease. The median time to progression for responders was 12 months. With a median follow-up of 23 months, the median overall survival was 43 months for survivors. The 3- and 5-year survival rates were 53% and 30%, respectively. Conclusion.: The combination of platinum and a taxane is a viable first-line treatment option for patients with ovarian carcinosarcoma. © 2007 Elsevier Inc. All rights reserved.
Keywords: adult; cancer survival; clinical article; controlled study; treatment outcome; aged; disease-free survival; middle aged; cancer surgery; survival rate; disease course; cisplatin; area under the curve; paclitaxel; neoadjuvant therapy; cancer staging; neoplasm staging; cytoreductive surgery; ovarian neoplasms; carboplatin; multiple cycle treatment; antineoplastic combined chemotherapy protocols; docetaxel; sarcoma; cancer center; medical record; ovary carcinoma; platinum; platinum derivative; taxoids; taxane derivative; organoplatinum compounds; carcinosarcoma; taxane; data extraction; ovarian carcinosarcoma
Journal Title: Gynecologic Oncology
Volume: 105
Issue: 3
ISSN: 0090-8258
Publisher: Elsevier Inc.  
Date Published: 2007-06-01
Start Page: 657
End Page: 661
Language: English
DOI: 10.1016/j.ygyno.2007.01.037
PUBMED: 17395252
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 12" - "Export Date: 17 November 2011" - "CODEN: GYNOA" - "Source: Scopus"
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MSK Authors
  1. Aliza Leah Leiser
    8 Leiser
  2. Dennis S Chi
    496 Chi
  3. William P Tew
    123 Tew
  4. Nicole Marie Leoce
    86 Leoce