Regulation of the protein kinase activity of the human insulin receptor Journal Article
| Authors: | Herrera, R.; Rosen, O. M. |
| Article Title: | Regulation of the protein kinase activity of the human insulin receptor |
| Abstract: | The insulin receptor is a hormone-dependent protein tyrosine kinase that belongs to the family of tyrosine kinases associated with growth factor receptors and oncogene products. The activity of the insulin receptor kinase is regulated by the phosphorylation state of specific domains of the protein. Phosphorylation of the receptor on tyrosine residues activates its kinase activity whereas phosphorylation on serine and/or threonine residues inhibits it. In this review, we discuss the evidence that supports a role of the kinase activity of the receptor in the molecular mechanism of insulin action. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Keywords: | serine; enzyme activation; tyrosine; phosphorylation; insulin; short survey; threonine; protein kinase; phosphoprotein phosphatase; endocrine system; insulin receptor; protein-tyrosine kinase; human; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; receptor, insulin |
| Journal Title: | Journal of Receptor Research |
| Volume: | 7 |
| Issue: | 1-4 |
| ISSN: | 0197-5110 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 1987-01-01 |
| Start Page: | 405 |
| End Page: | 415 |
| Language: | English |
| DOI: | 10.3109/10799898709054995 |
| PUBMED: | 3040980 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
