Association of serum iron, serum transferrin saturation, and serum ferritin with survival in acute lymphocytic leukemia Journal Article
| Authors: | Potaznik, D.; Groshen, S.; Miller, D.; Bagin, R.; Bhalla, R.; Schwartz, M.; de Sousa, M. |
| Article Title: | Association of serum iron, serum transferrin saturation, and serum ferritin with survival in acute lymphocytic leukemia |
| Abstract: | The present investigation was motivated from the consideration that a host environment rich in iron, represented by high serum transferrin saturation (TS) and high serum iron and serum ferritin levels might offer favorable growth conditions for leukemic cells in addition to infection, thus affecting survival. Serum measurements were obtained on 113 pediatric patients with acute lympho-blastic leukemia (ALL), seen at Memorial Sloan-Kettering Cancer Center between May 20, 1981 and August 8, 1983. A significant difference (p < 0.001) was found between the survival of patients according to whether their first measured TS was >36% or <36%, with fewer deaths in the group with TS <36. The relationship between TS and survival was still observed when patients were stratified according to length of time from diagnosis, risk group, French-American-British (FAB) classification, or presence of organomegaly at diagnosis (p < 0.001). Similar differences were observed between survival of patients grouped according to their first measured serum ferritin. These results independently confirm and extend observations presented earlier and support the consideration that motivated this study. The value of serum iron-related measurements as prognostic variables cannot be established from this type of study; however, these findings suggest the need for a prospective study. © 1987 Raven Press, Ltd., New York. |
| Keywords: | survival; child; clinical article; child, preschool; acute lymphoblastic leukemia; infant; iron; childhood leukemia; ferritin; transferrin; serum ferritin; iron blood level; leukemia, lymphocytic; prognosis; human; male; female; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; pediatric all; serum iron; serum transferrin saturation |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 9 |
| Issue: | 4 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1987-01-01 |
| Start Page: | 350 |
| End Page: | 355 |
| Language: | English |
| DOI: | 10.1097/00043426-198724000-00014 |
| PUBMED: | 3484368 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Publication date is Winter 1987 -- Export Date: 5 February 2021 -- Source: Scopus |
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