Residual mass: An indication for further therapy in patients with advanced seminoma following systemic chemotherapy Journal Article
| Authors: | Motzer, R.; Bosl, G.; Heelan, R.; Fair, W.; Whitmore, W.; Sogani, P.; Herr, H.; Morse, M. |
| Article Title: | Residual mass: An indication for further therapy in patients with advanced seminoma following systemic chemotherapy |
| Abstract: | Forty-one advanced seminoma patients with normal biochemical markers and a complete or partial radiographic response after cisplatin-based chemotherapy had a complete reevaluation of all known sites of disease. Twenty-three patients had a residual mass, and in 14 the mass was ≥ 3 cm. Nineteen patients with a residual mass, including 13 with a mass ≥ 3 cm in diameter, had surgical excision or biopsy. Four patients had viable seminoma and one patient had teratoma; all five of these patients had residual masses ≥ 3 cm. Four patients with a residual mass were observed without surgery. One patient with a residual mass ≥ 3 cm progressed with biopsy-proven seminoma. Therefore, six of 14 patients (42%) with a residual mass ≥ 3 cm had viable residual tumor. Eighteen patients had no residual mass after chemotherapy. Ten of these patients had surgery or biopsy; none had viable tumor, but two have relapsed. Advanced seminoma patients with a residual mass ≥ 3 cm after chemotherapy are at high risk for residual viable tumor. Additional therapy is indicated for these patients. For patients with normal imaging studies or a residual mass < 3 cm, close observation without surgery is generally possible. |
| Keywords: | clinical article; cisplatin; advanced cancer; etoposide; testis cancer; seminoma; human; male |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 5 |
| Issue: | 7 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 1987-07-01 |
| Start Page: | 1064 |
| End Page: | 1070 |
| Language: | English |
| DOI: | 10.1200/jco.1987.5.7.1064 |
| PUBMED: | 3598610 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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