Protein synthesis in hepatocytes isolated from patients with gastrointestinal malignancy Journal Article
| Authors: | Starnes, H. F. Jr; Warren, R. S.; Brennan, M. F. |
| Article Title: | Protein synthesis in hepatocytes isolated from patients with gastrointestinal malignancy |
| Abstract: | To investigate the effect of remote and proximate cancer on hepatic protein metabolism, we determined rates of total protein synthesis by hepatocytes (HPS) isolated from 31 patients undergoing liver wedge biopsy: 7 patients with benign disease, 14 with gastric cancer, and 10 with colorectal cancer (5 of whom had liver metastases). Patients with malignant disease without weight loss had a threefold higher rate of total HPS (4,980 ± 814 pmol/h per 105 viable cells) than patients with benign disease without weight loss (1,278 ± 318 pmol/h per 105 viable cells, P < 0.001). Among the patients with gastric cancer, eight with preoperative weight loss had lower rates of HPS (380 ± 90 pmol/h per 105 viable cells) than those without weight loss (4,061 ± 401 pmol/h per 105 viable cells, P < 0.002). The highest rates of HPS were seen in patients with colorectal cancer with liver metastases (8,005 ± 1,975 pmol/h per 105 viable cells) vs. colorectal cancer patients without liver metastases (3,060 ± 575 pmol/h per 105 viable cells, P < 0.03). These data indicate that modulation of hepatic protein synthesis occurs in malignancy in man. However, the stimulatory influence of the tumor-bearing state may be overridden by the inhibitory effects of cachexia. |
| Keywords: | clinical article; colorectal cancer; digestive system cancer; liver metastasis; protein synthesis; stomach cancer; cachexia; liver cell; human; male; female; priority journal |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 80 |
| Issue: | 5 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 1987-11-01 |
| Start Page: | 1384 |
| End Page: | 1390 |
| Language: | English |
| DOI: | 10.1172/jci113216 |
| PUBMED: | 3680502 |
| PROVIDER: | scopus |
| PMCID: | PMC442394 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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