The cardiotoxic effect of epirubicin and doxorubicin (Adriamycin): A clinical and radionuclide cine-angiographic comparison Journal Article

  


Author: Casper, E. S.
Article Title: The cardiotoxic effect of epirubicin and doxorubicin (Adriamycin): A clinical and radionuclide cine-angiographic comparison
Abstract: Epirubicin has undergone extensive evaluation at the Memorial Sloan-Kettering Cancer Center. A prospective randomized comparison of epirubicin and doxorubicin (Adriamycin) in the treatment of breast cancer was made. Cardiac toxicity was evaluated clinically and with the use of radionuclide cine-angiography. A gradual decline in left ventricular ejection fraction was not consistently seen, but radionuclide angiographic abnormalities correlated well with clinical performance. Radionuclide cine-angiography was an inadequate predictor of impending cardiac failure in any particular patient. On a molar basis, epirubicin is less cardiotoxic than doxorubicin. Even allowing for the difference in myelosuppressive potency between the two drugs, epirubicin is less cardiotoxic.
Keywords: controlled study; major clinical study; clinical trial; doxorubicin; breast cancer; randomized controlled trial; cardiotoxicity; epirubicin; radioisotope; human; female; cineangiography
Journal Title: Clinical Trials Journal
Volume: 24
Issue: Suppl. 1
ISSN: 0009-9325
Publisher: Elsevier B.V.  
Date Published: 1987-01-01
Start Page: 57
End Page: 67
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023585147&partnerID=40&md5=5fec03fff351fcd0de30df4fd88bc0a9
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus